6OFY

Crystal Structure of Arachidonic Acid bound to V349I murine COX-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Prostaglandin G/H synthase 2	polymer	552	63612.6	2	UniProt (Q05769) Pfam (PF00008) Pfam (PF03098)	Mus musculus (Mouse)	Cyclooxygenase-2,COX-2,Glucocorticoid-regulated inflammatory cyclooxygenase,Gripghs,Macrophage activation-associated marker protein P71/73,PES-2,PHS II,Prostaglandin H2 synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2,TIS10 protein
2	C, D, E, F, K... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
3	G, O (A, B)	PROTOPORPHYRIN IX CONTAINING CO	non-polymer		619.6	2	Chemie (COH)
4	H (A)	octyl beta-D-glucopyranoside	non-polymer		292.4	1	Chemie (BOG)
5	I (A)	ACRYLIC ACID	non-polymer		72.1	1	Chemie (AKR) PubChem (6581)
6	J, P (A, B)	ARACHIDONIC ACID	non-polymer		304.5	2	Chemie (ACD) PubChem (114670) PubChem (444899) PubChem (5312542) PubChem (12083498) PubChem (12096305) PubChem (12111897) PubChem (12183869) PubChem (12358407) PubChem (12358409) PubChem (12358410) PubChem (12358414) PubChem (12990988) PubChem (231) PubChem (122652008) PubChem (87131823) PubChem (87196993) PubChem (92449654) PubChem (122651992) PubChem (122652036) PubChem (122652077) PubChem (173636367) PubChem (173785266) PubChem (174059456) PubChem (175709969) PubChem (175736020) PubChem (175951410)
7	Q, R (A, B)	water	water		18.0	718	Chemie (HOH)

Sequence modifications

A, B: 35 - 583 (UniProt: Q05769)

PDB	External Database	Details
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
Ile 350	Val 335	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	127225.2
Non-Polymers*	Number of molecules	14
	Total formula weight	3982.2
All*	Total formula weight	131207.4

*Water molecules are not included.