6OFY
Crystal Structure of Arachidonic Acid bound to V349I murine COX-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prostaglandin G/H synthase 2 | polymer | 552 | 63612.6 | 2 | UniProt (Q05769) Pfam (PF00008) Pfam (PF03098) | Mus musculus (Mouse) | Cyclooxygenase-2,COX-2,Glucocorticoid-regulated inflammatory cyclooxygenase,Gripghs,Macrophage activation-associated marker protein P71/73,PES-2,PHS II,Prostaglandin H2 synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2,TIS10 protein |
| 2 | C, D, E, F, K... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 3 | G, O (A, B) | PROTOPORPHYRIN IX CONTAINING CO | non-polymer | 619.6 | 2 | Chemie (COH) | |||
| 4 | H (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 5 | I (A) | ACRYLIC ACID | non-polymer | 72.1 | 1 | Chemie (AKR) | |||
| 6 | J, P (A, B) | ARACHIDONIC ACID | non-polymer | 304.5 | 2 | Chemie (ACD) | |||
| 7 | Q, R (A, B) | water | water | 18.0 | 718 | Chemie (HOH) |
Sequence modifications
A, B: 35 - 583 (UniProt: Q05769)
| PDB | External Database | Details |
|---|---|---|
| His 32 | - | expression tag |
| His 33 | - | expression tag |
| His 34 | - | expression tag |
| Ile 350 | Val 335 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127225.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3982.2 | |
| All* | Total formula weight | 131207.4 |
