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3DSH
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BU of 3dsh by Molmil
Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain
分子名称: Interferon regulatory factor 5
著者Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E.
登録日2008-07-12
公開日2008-10-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
8T5K
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BU of 8t5k by Molmil
Crystal structure of STING CTD in complex with BDW-OH
分子名称: Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
8T5L
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BU of 8t5l by Molmil
Crystal structure of STING CTD in complex with 2'3'-cGAMP
分子名称: Stimulator of interferon genes protein, cGAMP
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
5KVD
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BU of 5kvd by Molmil
Zika specific antibody, ZV-2, bound to ZIKA envelope DIII
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ...
著者Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2016-07-14
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
6MYD
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BU of 6myd by Molmil
Structure of zebrafish TRAF6 in complex with STING CTT
分子名称: STING CTT, Transmembrane protein 173, SULFATE ION, ...
著者de Oliveira Mann, C.C, Orzalli, M.H, King, D.S, Kagan, J.C, Lee, A.S.Y, Kranzusch, P.J.
登録日2018-11-01
公開日2019-05-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation.
Cell Rep, 27, 2019
6NT9
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BU of 6nt9 by Molmil
Cryo-EM structure of the complex between human TBK1 and chicken STING
分子名称: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
著者Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
登録日2019-01-28
公開日2019-03-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 567, 2019
4MKP
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BU of 4mkp by Molmil
Crystal structure of human cGAS apo form
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Kato, K, Ishii, R, Ishitani, R, Nureki, O.
登録日2013-09-05
公開日2013-10-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.953 Å)
主引用文献Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
Plos One, 8, 2013
7X9P
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Crystal structure of human STING complexed with compound BSP17
分子名称: 4-[6-methoxy-5-[3-[[6-methoxy-2-(4-oxidanyl-4-oxidanylidene-butanoyl)-1-benzoselenophen-5-yl]oxy]propoxy]-1-benzoselenophen-2-yl]-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein
著者Pan, L, Guan, X, Feng, X, Li, Z, Bian, J.
登録日2022-03-15
公開日2023-03-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Selenium-containing STING agonists as orally available anti tumor agents
To be published
7OB3
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hSTING in complex with 3',3'-c-di-araAMP
分子名称: 3',3'-c-di-araAMP, Stimulator of interferon genes protein
著者Smola, M, Boura, E.
登録日2021-04-20
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Biochemistry, 2021
4XR8
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BU of 4xr8 by Molmil
Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ...
著者Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K.
登録日2015-01-20
公開日2016-02-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Nature, 529, 2016
6S27
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BU of 6s27 by Molmil
Crystal structure of human wild type STING in complex with 2'3'-cyclic-GMP-2'F-2'dAMP
分子名称: 2'3'-cyclic-GMP-2'F-2'dAMP, Stimulator of interferon protein
著者Smola, M, Boura, E.
登録日2019-06-20
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
J.Med.Chem., 62, 2019
3JRV
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BU of 3jrv by Molmil
Structure of poxvirus K7 protein in complex with RNA helicase DDX3
分子名称: ATP-dependent RNA helicase DDX3X, Protein K7
著者Oda, S, Khan, R.A.
登録日2009-09-09
公開日2009-11-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7
Structure, 17, 2009
7R4H
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BU of 7r4h by Molmil
phospho-STING binding to adaptor protein complex-1
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Xu, P, Ablasser, A.
登録日2022-02-08
公開日2022-09-14
最終更新日2022-11-09
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Clathrin-associated AP-1 controls termination of STING signalling.
Nature, 610, 2022
7SII
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BU of 7sii by Molmil
Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)
分子名称: 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, Stimulator of interferon genes protein, cGAMP
著者Lu, D, Shang, G, Jie, L, Lu, Y, Bai, X.C, Zhang, X.
登録日2021-10-14
公開日2022-02-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Activation of STING by targeting a pocket in the transmembrane domain.
Nature, 604, 2022
7YPE
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BU of 7ype by Molmil
Crystal structure of AsfvPCNA in space group of P63
分子名称: E301R, GLYCEROL
著者Shao, Z.W, Gan, J.H.
登録日2022-08-03
公開日2023-07-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and functional studies of PCNA from African swine fever virus.
J.Virol., 97, 2023
4YP1
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Misting with CDA
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein
著者Chin, K.H, Chen, C.K, Tu, Z.I, Chou, S.H.
登録日2015-03-12
公開日2015-10-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK.
Biochemistry, 54, 2015
7YPF
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Crystal structure of AsfvPCNA in space group of P1
分子名称: E301R
著者Shao, Z.W, Gan, J.H.
登録日2022-08-03
公開日2023-08-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and functional studies of PCNA from African swine fever virus.
J.Virol., 97, 2023
7Q85
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BU of 7q85 by Molmil
Crystal structure of human STING in complex with MD1193
分子名称: 9-[(1R,6R,8R,13E,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,16-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadec-13-en-8-yl]purin-6-amine, Stimulator of interferon genes protein
著者Smola, M, Klima, M, Boura, E.
登録日2021-11-10
公開日2022-10-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.359 Å)
主引用文献Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Eur.J.Med.Chem., 259, 2023
7Q3B
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BU of 7q3b by Molmil
Crystal structure of human STING in complex with 3'3'-c-(2'F,2'dA-isonucA)MP
分子名称: 3'3'-c-(2'F,2'dA-isonucA)MP, Stimulator of interferon genes protein
著者Smola, M, Klima, M, Boura, E.
登録日2021-10-27
公開日2022-06-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.55733919 Å)
主引用文献Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure, 30, 2022
6GYT
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BU of 6gyt by Molmil
Transcription factor dimerization activates the p300 acetyltransferase
分子名称: Histone H4, Histone acetyltransferase p300, ZINC ION
著者Panne, D, Ortega, E.
登録日2018-07-01
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Transcription factor dimerization activates the p300 acetyltransferase.
Nature, 562, 2018
6GYR
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BU of 6gyr by Molmil
Transcription factor dimerization activates the p300 acetyltransferase
分子名称: Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
著者Panne, D, Ortega, E.
登録日2018-07-01
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Transcription factor dimerization activates the p300 acetyltransferase.
Nature, 562, 2018
7LDK
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BU of 7ldk by Molmil
Structure of human respiratory syncytial virus nonstructural protein 2 (NS2)
分子名称: CHLORIDE ION, D(-)-TARTARIC ACID, Non-structural protein 2
著者Chatterjee, S, Borek, D, Otwinowski, Z, Amarasinghe, G.K, Leung, D.W.
登録日2021-01-13
公開日2021-03-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
5BQX
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BU of 5bqx by Molmil
Crystal structure of human STING in complex with 3'2'-cGAMP
分子名称: 3'2'-cGAMP, Stimulator of interferon genes protein
著者Wu, J, Zhang, X, Chen, Z.J, Chen, C.
登録日2015-05-29
公開日2015-06-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
7MHC
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BU of 7mhc by Molmil
Structure of human STING in complex with MK-1454
分子名称: (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者Lesburg, C.A.
登録日2021-04-15
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature, 603, 2022
8ITE
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Crystal structure of pE301R from African swine fever virus
分子名称: Uncharacterized protein E301R
著者Zhang, H, Li, Y.H.
登録日2023-03-22
公開日2023-09-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The E301R protein of African swine fever virus functions as a sliding clamp involved in viral genome replication.
Mbio, 14, 2023

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