3DSH
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![BU of 3dsh by Molmil](/molmil-images/mine/3dsh) | Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain | 分子名称: | Interferon regulatory factor 5 | 著者 | Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E. | 登録日 | 2008-07-12 | 公開日 | 2008-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat.Struct.Mol.Biol., 15, 2008
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5KVD
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![BU of 5kvd by Molmil](/molmil-images/mine/5kvd) | Zika specific antibody, ZV-2, bound to ZIKA envelope DIII | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ... | 著者 | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-07-14 | 公開日 | 2016-08-03 | 最終更新日 | 2016-08-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis of Zika Virus-Specific Antibody Protection. Cell, 166, 2016
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8T5K
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![BU of 8t5k by Molmil](/molmil-images/mine/8t5k) | Crystal structure of STING CTD in complex with BDW-OH | 分子名称: | Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid | 著者 | Li, Y, Li, P, Sun, D. | 登録日 | 2023-06-13 | 公開日 | 2023-07-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants. Biorxiv, 2023
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8T5L
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![BU of 8t5l by Molmil](/molmil-images/mine/8t5l) | |
6MYD
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![BU of 6myd by Molmil](/molmil-images/mine/6myd) | Structure of zebrafish TRAF6 in complex with STING CTT | 分子名称: | STING CTT, Transmembrane protein 173, SULFATE ION, ... | 著者 | de Oliveira Mann, C.C, Orzalli, M.H, King, D.S, Kagan, J.C, Lee, A.S.Y, Kranzusch, P.J. | 登録日 | 2018-11-01 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation. Cell Rep, 27, 2019
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6NT9
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![BU of 6nt9 by Molmil](/molmil-images/mine/6nt9) | Cryo-EM structure of the complex between human TBK1 and chicken STING | 分子名称: | Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | 著者 | Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. | 登録日 | 2019-01-28 | 公開日 | 2019-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of STING binding with and phosphorylation by TBK1. Nature, 567, 2019
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4MKP
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![BU of 4mkp by Molmil](/molmil-images/mine/4mkp) | Crystal structure of human cGAS apo form | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | 登録日 | 2013-09-05 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | 主引用文献 | Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Plos One, 8, 2013
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7OB3
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![BU of 7ob3 by Molmil](/molmil-images/mine/7ob3) | hSTING in complex with 3',3'-c-di-araAMP | 分子名称: | 3',3'-c-di-araAMP, Stimulator of interferon genes protein | 著者 | Smola, M, Boura, E. | 登録日 | 2021-04-20 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations Biochemistry, 2021
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6YWA
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![BU of 6ywa by Molmil](/molmil-images/mine/6ywa) | |
4XR8
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![BU of 4xr8 by Molmil](/molmil-images/mine/4xr8) | Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | 著者 | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | 登録日 | 2015-01-20 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
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6DNK
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![BU of 6dnk by Molmil](/molmil-images/mine/6dnk) | Human Stimulator of Interferon Genes | 分子名称: | Stimulator of interferon genes protein, cGAMP | 著者 | Fernandez, D, Li, L, Ergun, S.L. | 登録日 | 2018-06-06 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178, 2019
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2K36
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![BU of 2k36 by Molmil](/molmil-images/mine/2k36) | Structure ensemble Backbone and side-chain 1H, 13C, and 15N Chemical Shift Assignments, 1H-15N RDCs and 1H-1H nOe restraints for protein K7 from the Vaccinia virus | 分子名称: | Protein K7 | 著者 | Kalverda, A.P, Thompson, G.S, Vogel, A, Schr der, M, Bowie, A.G, Khan, A.R, Homans, S.W. | 登録日 | 2008-04-22 | 公開日 | 2008-10-28 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3. J.Mol.Biol., 385, 2009
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6GYR
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![BU of 6gyr by Molmil](/molmil-images/mine/6gyr) | Transcription factor dimerization activates the p300 acetyltransferase | 分子名称: | Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | 著者 | Panne, D, Ortega, E. | 登録日 | 2018-07-01 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Transcription factor dimerization activates the p300 acetyltransferase. Nature, 562, 2018
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3JRV
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![BU of 3jrv by Molmil](/molmil-images/mine/3jrv) | |
6GYT
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![BU of 6gyt by Molmil](/molmil-images/mine/6gyt) | |
7F60
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![BU of 7f60 by Molmil](/molmil-images/mine/7f60) | |
7LDK
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![BU of 7ldk by Molmil](/molmil-images/mine/7ldk) | Structure of human respiratory syncytial virus nonstructural protein 2 (NS2) | 分子名称: | CHLORIDE ION, D(-)-TARTARIC ACID, Non-structural protein 2 | 著者 | Chatterjee, S, Borek, D, Otwinowski, Z, Amarasinghe, G.K, Leung, D.W. | 登録日 | 2021-01-13 | 公開日 | 2021-03-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2. Proc.Natl.Acad.Sci.USA, 118, 2021
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7T9V
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![BU of 7t9v by Molmil](/molmil-images/mine/7t9v) | Crystal structure of hSTING with the agonist, SHR171032 | 分子名称: | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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7T9U
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![BU of 7t9u by Molmil](/molmil-images/mine/7t9u) | Crystal structure of hSTING with an agonist (SHR169224) | 分子名称: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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4YP1
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![BU of 4yp1 by Molmil](/molmil-images/mine/4yp1) | Misting with CDA | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein | 著者 | Chin, K.H, Chen, C.K, Tu, Z.I, Chou, S.H. | 登録日 | 2015-03-12 | 公開日 | 2015-10-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK. Biochemistry, 54, 2015
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7MHC
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![BU of 7mhc by Molmil](/molmil-images/mine/7mhc) | Structure of human STING in complex with MK-1454 | 分子名称: | (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Lesburg, C.A. | 登録日 | 2021-04-15 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | A kinase-cGAS cascade to synthesize a therapeutic STING activator. Nature, 603, 2022
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6CFF
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![BU of 6cff by Molmil](/molmil-images/mine/6cff) | Stimulator of Interferon Genes Human | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein | 著者 | Fernandez, D, Li, L, Ergun, S.L. | 登録日 | 2018-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178, 2019
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7X9P
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![BU of 7x9p by Molmil](/molmil-images/mine/7x9p) | Crystal structure of human STING complexed with compound BSP17 | 分子名称: | 4-[6-methoxy-5-[3-[[6-methoxy-2-(4-oxidanyl-4-oxidanylidene-butanoyl)-1-benzoselenophen-5-yl]oxy]propoxy]-1-benzoselenophen-2-yl]-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein | 著者 | Pan, L, Guan, X, Feng, X, Li, Z, Bian, J. | 登録日 | 2022-03-15 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Selenium-containing STING agonists as orally available anti tumor agents To be published
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6X5A
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![BU of 6x5a by Molmil](/molmil-images/mine/6x5a) | The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells | 分子名称: | Cyclic GMP-AMP synthase, DNA (natural), Histone H2A type 1, ... | 著者 | Pengbiao, X, Pingwei, L, Baoyu, Z. | 登録日 | 2020-05-25 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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7UAJ
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![BU of 7uaj by Molmil](/molmil-images/mine/7uaj) | Crystal structure of apo HPV16 E6 | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Protein E6, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Shen, Q, Leonard, P.G, Cross, J.B. | 登録日 | 2022-03-13 | 公開日 | 2023-03-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Disorder-to-order transition of the interdomain linker of HPV E6 upon E6AP binding reshapes p53 binding pocket To Be Published
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