PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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4M4Z	SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2) 分子名称: Src-like-adapter 2 著者 Wybenga-Groot, L.E, McGlade, C.J. 登録日 2013-08-07 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation. Cell Signal, 25, 2013
4L1B	Crystal Structure of p110alpha complexed with niSH2 of p85alpha 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, SULFATE ION 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-03 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.586 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
1XA6	Crystal Structure of the Human Beta2-Chimaerin 分子名称: Beta2-chimaerin, ZINC ION 著者 Canagarajah, B, Leskow, F.C, Ho, J.Y, Mischak, H, Saidi, L.F, Kazanietz, M.G, Hurley, J.H. 登録日 2004-08-25 公開日 2004-11-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell(Cambridge,Mass.), 119, 2004
7YQE	Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54. 分子名称: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor 著者 Song, G, Xu, S. 登録日 2022-08-06 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun, 15, 2024
4LUD	Crystal Structure of HCK in complex with the fluorescent compound SKF86002 分子名称: 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, CHLORIDE ION, ... 著者 Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. 登録日 2013-07-25 公開日 2014-02-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
4L2Y	Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d 分子名称: 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-05 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
4LUE	Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (resulting from displacement of SKF86002) 分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. 登録日 2013-07-25 公開日 2014-02-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
7ZLO	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 12 分子名称: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
7ZLP	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 分子名称: Elongin-B, Elongin-C, PHOSPHATE ION, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
7ZLN	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11 分子名称: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
7ZLS	co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 分子名称: 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
7ZLR	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 分子名称: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
7ZLM	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551 分子名称: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
4L23	Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-04 公開日 2014-01-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
4K2R	Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker 分子名称: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Yan, Q, Barros, T, Visperas, P.R, Deindl, S, Kadlecek, T.A, Weiss, A, Kuriyan, J. 登録日 2013-04-09 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker. Mol.Cell.Biol., 33, 2013
7ZN7	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-20 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
7ZNN	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-21 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
7Z3J	Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... 著者 Pinotsis, N, Bunney, T.D, Katan, M. 登録日 2022-03-02 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. Sci Adv, 8, 2022
8AM0	Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) 分子名称: (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Goncalves, M, Johnson, J.L, Roewer, K.M. 登録日 2022-08-02 公開日 2023-12-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.818 Å) 主引用文献 Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42, 2023
1Y57	Structure of unphosphorylated c-Src in complex with an inhibitor 分子名称: 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION 著者 Cowan-Jacob, S.W, Fendrich, G, Manley, P.W, Jahnke, W, Fabbro, D, Liebetanz, J, Meyer, T. 登録日 2004-12-02 公開日 2005-06-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation Structure, 13, 2005
2ABL	SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE 分子名称: ABL TYROSINE KINASE 著者 Nam, H.-J, Frederick, C.A. 登録日 1996-11-17 公開日 1997-09-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. Structure, 4, 1996
1Y1U	Structure of unphosphorylated STAT5a 分子名称: Signal transducer and activator of transcription 5A 著者 Neculai, D, Neculai, A.M, Verrier, S, Straub, K, Klumpp, K, Pfitzner, E, Becker, S. 登録日 2004-11-19 公開日 2005-10-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structure of the unphosphorylated STAT5a dimer J.Biol.Chem., 280, 2005
1YVL	Structure of Unphosphorylated STAT1 分子名称: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta 著者 Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X. 登録日 2005-02-16 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural bases of unphosphorylated STAT1 association and receptor binding. Mol.Cell, 17, 2005
4NWF	Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. 登録日 2013-12-06 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation To be Published
4NWG	Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. 登録日 2013-12-06 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation To be Published

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