4K2R

Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker

Summary for 4K2R

Entry DOI	10.2210/pdb4k2r/pdb
Descriptor	Tyrosine-protein kinase ZAP-70, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	kinase domain, sh2 domain, transferase, atp binding, cytoplam
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P43403
Total number of polymer chains	1
Total formula weight	70181.36
Authors	Yan, Q.,Barros, T.,Visperas, P.R.,Deindl, S.,Kadlecek, T.A.,Weiss, A.,Kuriyan, J. (deposition date: 2013-04-09, release date: 2013-05-08, Last modification date: 2024-02-28)
Primary citation	Yan, Q.,Barros, T.,Visperas, P.R.,Deindl, S.,Kadlecek, T.A.,Weiss, A.,Kuriyan, J. Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker. Mol.Cell.Biol., 33:2188-2201, 2013 Cited by PubMed: 23530057 DOI: 10.1128/MCB.01637-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation