4K2R
Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase ZAP-70 | polymer | 614 | 69555.9 | 1 | UniProt (P43403) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence modifications
A: 1 - 606 (UniProt: P43403)
| PDB | External Database | Details |
|---|---|---|
| Asn 461 | Asp 461 | engineered mutation |
| Gly 607 | - | expression tag |
| Ser 608 | - | expression tag |
| Gly 609 | - | expression tag |
| Leu 610 | - | expression tag |
| Glu 611 | - | expression tag |
| Val 612 | - | expression tag |
| Leu 613 | - | expression tag |
| Phe 614 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 69555.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 625.5 | |
| All* | Total formula weight | 70181.4 |
