1Y57
Structure of unphosphorylated c-Src in complex with an inhibitor
Summary for 1Y57
Entry DOI | 10.2210/pdb1y57/pdb |
Related | 1FMK 1KSW 2PTK 2SRC |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, ... (4 entities in total) |
Functional Keywords | kinase structure, sh3, sh2, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: P12931 |
Total number of polymer chains | 1 |
Total formula weight | 52589.48 |
Authors | Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.W.,Jahnke, W.,Fabbro, D.,Liebetanz, J.,Meyer, T. (deposition date: 2004-12-02, release date: 2005-06-21, Last modification date: 2024-03-13) |
Primary citation | Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.W.,Jahnke, W.,Fabbro, D.,Liebetanz, J.,Meyer, T. The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation Structure, 13:861-871, 2005 Cited by PubMed: 15939018DOI: 10.1016/j.str.2005.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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