1KSW

Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP

Summary for 1KSW

• Entry DOI: 10.2210/pdb1ksw/pdb
• Related: 1FMK 2SRC
• Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N6-BENZYL ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: sh3, sh2, kinase, bump hole, bump-hole, chemical genetics, orthogonal substrate, atp, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: P12931
• Total number of polymer chains: 1
• Total formula weight: 52182.84

Authors

Witucki, L.A.,Huang, X.,Shah, K.,Liu, Y.,Kyin, S.,Eck, M.J.,Shokat, K.M. (deposition date: 2002-01-14, release date: 2002-02-27, Last modification date: 2023-11-15)

• Primary citation: Witucki, L.A.,Huang, X.,Shah, K.,Liu, Y.,Kyin, S.,Eck, M.J.,Shokat, K.M.; Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.; Chem.Biol., 9:25-33, 2002; PubMed: 11841936; DOI: 10.1016/S1074-5521(02)00091-1

Experimental method

X-RAY DIFFRACTION (2.8 Å)