1KSW
Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP
Summary for 1KSW
Entry DOI | 10.2210/pdb1ksw/pdb |
Related | 1FMK 2SRC |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N6-BENZYL ADENOSINE-5'-DIPHOSPHATE (3 entities in total) |
Functional Keywords | sh3, sh2, kinase, bump hole, bump-hole, chemical genetics, orthogonal substrate, atp, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: P12931 |
Total number of polymer chains | 1 |
Total formula weight | 52182.84 |
Authors | Witucki, L.A.,Huang, X.,Shah, K.,Liu, Y.,Kyin, S.,Eck, M.J.,Shokat, K.M. (deposition date: 2002-01-14, release date: 2002-02-27, Last modification date: 2023-11-15) |
Primary citation | Witucki, L.A.,Huang, X.,Shah, K.,Liu, Y.,Kyin, S.,Eck, M.J.,Shokat, K.M. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9:25-33, 2002 Cited by PubMed: 11841936DOI: 10.1016/S1074-5521(02)00091-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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