4L23

Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103

Summary for 4L23

• Entry DOI: 10.2210/pdb4l23/pdb
• Related: 4L1B 4L2Y
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, ... (6 entities in total)
• Functional Keywords: atp binding, pi-103, signaling protein-transferase-inhibitor complex, signaling protein/transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 164129.04

Authors

Zhang, J.,Zhao, Y.L.,Chen, Y.Y.,Huang, M.,Jiang, F. (deposition date: 2013-06-04, release date: 2014-01-01, Last modification date: 2024-02-28)

• Primary citation: Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J.; Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.; ACS Med Chem Lett, 5:138-142, 2014; PubMed: 24900786; DOI: 10.1021/ml400378e

Experimental method

X-RAY DIFFRACTION (2.501 Å)