4L2Y

Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d

Summary for 4L2Y

• Entry DOI: 10.2210/pdb4l2y/pdb
• Related: 4L1B 4L23
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, ... (6 entities in total)
• Functional Keywords: atp binding, signaling protein-transferase-inhibitor complex, signaling protein/transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 164144.06

Authors

Zhang, J.,Zhao, Y.L.,Chen, Y.Y.,Huang, M.,Jiang, F. (deposition date: 2013-06-05, release date: 2014-01-01, Last modification date: 2023-09-20)

• Primary citation: Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J.; Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.; ACS Med Chem Lett, 5:138-142, 2014; PubMed: 24900786; DOI: 10.1021/ml400378e

Experimental method

X-RAY DIFFRACTION (2.8 Å)