4L2Y
Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1068 | 124445.0 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA |
2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 324 | 39051.5 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) In PDB | Homo sapiens (human) | PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha |
3 | A | 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol | non-polymer | 363.4 | 1 | Chemie (XXK) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
B: 318 - 615 (UniProt: P27986)
PDB | External Database | Details |
---|---|---|
Met 292 | - | expression tag |
Ser 293 | - | expression tag |
Tyr 294 | - | expression tag |
Tyr 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
His 298 | - | expression tag |
His 299 | - | expression tag |
His 300 | - | expression tag |
His 301 | - | expression tag |
Asp 302 | - | expression tag |
Tyr 303 | - | expression tag |
Asp 304 | - | expression tag |
Ile 305 | - | expression tag |
Pro 306 | - | expression tag |
Thr 307 | - | expression tag |
Thr 308 | - | expression tag |
Glu 309 | - | expression tag |
Asn 310 | - | expression tag |
Leu 311 | - | expression tag |
Tyr 312 | - | expression tag |
Phe 313 | - | expression tag |
Gln 314 | - | expression tag |
Ser 315 | - | expression tag |
Ile 316 | - | expression tag |
Ala 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 163496.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 647.6 | |
All* | Total formula weight | 164144.1 |