4L23
Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1068 | 124445.0 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA |
| 2 | B (B) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 324 | 39051.5 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) | Homo sapiens (human) | PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | C (A) | 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL | non-polymer | 348.4 | 1 | Chemie (X6K) | |||
| 4 | D, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
B: 318 - 615 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Met 292 | - | expression tag |
| Ser 293 | - | expression tag |
| Tyr 294 | - | expression tag |
| Tyr 295 | - | expression tag |
| His 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
| Asp 302 | - | expression tag |
| Tyr 303 | - | expression tag |
| Asp 304 | - | expression tag |
| Ile 305 | - | expression tag |
| Pro 306 | - | expression tag |
| Thr 307 | - | expression tag |
| Thr 308 | - | expression tag |
| Glu 309 | - | expression tag |
| Asn 310 | - | expression tag |
| Leu 311 | - | expression tag |
| Tyr 312 | - | expression tag |
| Phe 313 | - | expression tag |
| Gln 314 | - | expression tag |
| Ser 315 | - | expression tag |
| Ile 316 | - | expression tag |
| Ala 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 163496.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 632.6 | |
| All* | Total formula weight | 164129.0 |
