7ZLP
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9
Summary for 7ZLP
| Entry DOI | 10.2210/pdb7zlp/pdb |
| Descriptor | Suppressor of cytokine signaling 2, Elongin-B, Elongin-C, ... (6 entities in total) |
| Functional Keywords | e3 ligase, suppressor of cytokine signaling, ligase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 43995.06 |
| Authors | Ramachandran, S.,Ciulli, A.,Makukhin, N. (deposition date: 2022-04-15, release date: 2023-04-26, Last modification date: 2023-10-25) |
| Primary citation | Ramachandran, S.,Makukhin, N.,Haubrich, K.,Nagala, M.,Forrester, B.,Lynch, D.M.,Casement, R.,Testa, A.,Bruno, E.,Gitto, R.,Ciulli, A. Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14:6345-6345, 2023 Cited by PubMed: 37816714DOI: 10.1038/s41467-023-41894-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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