7ZLM

Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551

Summary for 7ZLM

• Entry DOI: 10.2210/pdb7zlm/pdb
• Descriptor: Suppressor of cytokine signaling 2, Elongin-B, Elongin-C, ... (5 entities in total)
• Functional Keywords: e3 ligase, suppressor of cytokine signaling, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 175894.36

Authors

Ramachandran, S.,Ciulli, A.,Makukhin, N. (deposition date: 2022-04-15, release date: 2023-04-26, Last modification date: 2023-10-25)

• Primary citation: Ramachandran, S.,Makukhin, N.,Haubrich, K.,Nagala, M.,Forrester, B.,Lynch, D.M.,Casement, R.,Testa, A.,Bruno, E.,Gitto, R.,Ciulli, A.; Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.; Nat Commun, 14:6345-6345, 2023; PubMed: 37816714; DOI: 10.1038/s41467-023-41894-3

Experimental method

X-RAY DIFFRACTION (1.79 Å)