7ZLM

Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0001222	molecular_function	transcription corepressor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0016567	biological_process	protein ubiquitination
B	0030891	cellular_component	VCB complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0070449	cellular_component	elongin complex
B	0140958	biological_process	target-directed miRNA degradation
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0035556	biological_process	intracellular signal transduction
E	0001222	molecular_function	transcription corepressor binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0016567	biological_process	protein ubiquitination
E	0030891	cellular_component	VCB complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0065003	biological_process	protein-containing complex assembly
E	0070449	cellular_component	elongin complex
E	0140958	biological_process	target-directed miRNA degradation
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0035556	biological_process	intracellular signal transduction
H	0001222	molecular_function	transcription corepressor binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0030891	cellular_component	VCB complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0065003	biological_process	protein-containing complex assembly
H	0070449	cellular_component	elongin complex
H	0140958	biological_process	target-directed miRNA degradation
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0035556	biological_process	intracellular signal transduction
K	0001222	molecular_function	transcription corepressor binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0016567	biological_process	protein ubiquitination
K	0030891	cellular_component	VCB complex
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0065003	biological_process	protein-containing complex assembly
K	0070449	cellular_component	elongin complex
K	0140958	biological_process	target-directed miRNA degradation
L	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
E	MET1
H	MET1
K	MET1

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
B	THR84
E	THR84
H	THR84
K	THR84
G	LYS173
J	LYS173

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site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
B	SER108
B	SER111
E	SER108
E	SER111
H	SER108
H	SER111
K	SER108
K	SER111

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