7ZLM

Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Suppressor of cytokine signaling 2	polymer	169	19273.3	4	UniProt (O14508) Pfam (PF00017) Pfam (PF07525)	Homo sapiens (human)	SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
2	B, E, H, K (B, E, H, K)	Elongin-B	polymer	118	13147.8	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3	C, F, I, L (C, F, I, L)	Elongin-C	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4	M, N, O, P (A, D, G, J)	[4-[(2~{S})-3-[[3-(2-chloranylethanoylamino)phenyl]methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate	non-polymer		577.9	4	Chemie (JIH)
5	AA, BA, Q, R, S... (K, L, A, B, C...)	water	water		18.0	919	Chemie (HOH)

Sequence modifications

A, D, G, J: 32 - 198 (UniProt: O14508)

PDB	External Database	Details
Ser 30	-	expression tag
Met 31	-	expression tag

C, F, I, L: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	173582.7
Non-Polymers*	Number of molecules	4
	Total formula weight	2311.7
All*	Total formula weight	175894.4

*Water molecules are not included.