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3PQR
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Crystal structure of Metarhodopsin II in complex with a C-terminal peptide derived from the Galpha subunit of transducin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, ...
著者Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P.
登録日2010-11-26
公開日2011-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal structure of metarhodopsin II.
Nature, 471, 2011
8IA8
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Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
分子名称: ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Liao, Q, Chen, G, Du, Y, Ye, R.D.
登録日2023-02-08
公開日2023-05-24
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
To Be Published
8IOC
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Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex
分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
著者Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S.
登録日2023-03-10
公開日2023-09-20
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
7EO4
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Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312
分子名称: 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者He, Y, Xu, Z, Ikuta, T, Inoue, A.
登録日2021-04-21
公開日2022-01-05
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat.Chem.Biol., 18, 2022
7VIE
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Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P
分子名称: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B.
登録日2021-09-26
公開日2022-09-28
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7PIV
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BU of 7piv by Molmil
Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.
分子名称: CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
登録日2021-08-23
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
6CM4
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Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone
分子名称: 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, D(2) dopamine receptor, endolysin chimera, ...
著者Wang, S, Che, T, Levit, A, Shoichet, B.K, Wacker, D, Roth, B.L.
登録日2018-03-02
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.867 Å)
主引用文献Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
Nature, 555, 2018
8JHY
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Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-25
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
7XAV
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BU of 7xav by Molmil
Structure of somatostatin receptor 2 bound with lanreotide.
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L.
登録日2022-03-19
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues.
Cell Discov, 8, 2022
8DWC
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BU of 8dwc by Molmil
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
分子名称: Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Liu, Y, Cao, C, Fay, J.F, Roth, B.L.
登録日2022-08-01
公開日2022-11-02
最終更新日2023-04-12
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.
Nat.Chem.Biol., 19, 2023
8HDO
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BU of 8hdo by Molmil
Structure of A2BR bound to synthetic agonists BAY 60-6583
分子名称: 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Adenosine A2b receptor, CHOLESTEROL, ...
著者Cai, H, Xu, Y, Xu, H.E, Jiang, Y.
登録日2022-11-05
公開日2023-01-18
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists.
Cell Discov, 8, 2022
7P02
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BU of 7p02 by Molmil
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
登録日2021-06-29
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
6FK8
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BU of 6fk8 by Molmil
Crystal structure of N2C/D282C stabilized opsin bound to RS08
分子名称: (2~{R},3~{S})-3-azanyl-2-(4-chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one, PALMITIC ACID, Rhodopsin, ...
著者Mattle, D, Standfuss, J, Dawson, R.
登録日2018-01-23
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7WCN
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Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
分子名称: Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qiao, A.N, Wu, S, Ye, S.
登録日2021-12-20
公開日2022-12-21
最終更新日2022-12-28
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Activation and signaling mechanism revealed by GPR119-G s complex structures.
Nat Commun, 13, 2022
7K15
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BU of 7k15 by Molmil
Crystal structure of the Human Leukotriene B4 Receptor 1 in Complex with Selective Antagonist MK-D-046
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, HEXAETHYLENE GLYCOL, ...
著者Michaelian, N, Han, G.W, Cherezov, V.
登録日2020-09-07
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Nat Commun, 12, 2021
8I95
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BU of 8i95 by Molmil
Structure of EP54-C3aR-Go complex
分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, EP54 ligand, ...
著者Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C.
登録日2023-02-06
公開日2023-10-18
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
8K8J
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BU of 8k8j by Molmil
Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Tang, W.Q, Wang, T.X, Li, F.H, Wang, J.Y.
登録日2023-07-30
公開日2024-02-14
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Fenofibrate Recognition and G q Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1.
Adv Sci, 11, 2024
8FN1
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BU of 8fn1 by Molmil
CryoEM structure of Go-coupled NTSR1
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ...
著者Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L.
登録日2022-12-26
公開日2023-03-29
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
4XT1
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Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ...
著者Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C.
登録日2015-01-22
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.886 Å)
主引用文献Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
7VUZ
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BU of 7vuz by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, Y, Yang, F.
登録日2021-11-04
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
8W8Q
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Cryo-EM structure of the GPR101-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y.
登録日2023-09-04
公開日2024-01-03
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
8J18
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Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
分子名称: (3R)-3-HYDROXYDODECANOIC ACID, Antibody fragment ScFv16, G-protein coupled receptor 84, ...
著者Liu, H, Yin, W, Xu, H.E.
登録日2023-04-12
公開日2023-06-21
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.
Nat Commun, 14, 2023
7EO2
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BU of 7eo2 by Molmil
Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p
分子名称: (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者He, Y, Xu, Z, Ikuta, T.
登録日2021-04-21
公開日2022-01-05
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat.Chem.Biol., 18, 2022
7VIG
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Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
分子名称: 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B.
登録日2021-09-26
公開日2022-09-28
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
8FN0
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CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator
分子名称: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L.
登録日2022-12-26
公開日2023-03-29
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023

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