7WCN

Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453

Summary for 7WCN

• Entry DOI: 10.2210/pdb7wcn/pdb
• EMDB information: 32425
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 144871.94

Authors

Qiao, A.N.,Wu, S.,Ye, S. (deposition date: 2021-12-20, release date: 2022-12-21, Last modification date: 2022-12-28)

• Primary citation: Qian, Y.,Wang, J.,Yang, L.,Liu, Y.,Wang, L.,Liu, W.,Lin, Y.,Yang, H.,Ma, L.,Ye, S.,Wu, S.,Qiao, A.; Activation and signaling mechanism revealed by GPR119-G s complex structures.; Nat Commun, 13:7033-7033, 2022; PubMed: 36396650; DOI: 10.1038/s41467-022-34696-6

Experimental method

ELECTRON MICROSCOPY (2.87 Å)