7K15

Crystal structure of the Human Leukotriene B4 Receptor 1 in Complex with Selective Antagonist MK-D-046

Summary for 7K15

• Entry DOI: 10.2210/pdb7k15/pdb
• Descriptor: Leukotriene B4 receptor 1,Flavodoxin,Leukotriene B4 receptor 1, N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide, SODIUM ION, ... (10 entities in total)
• Functional Keywords: human leukotriene b4 receptor 1, hblt1, blt1, bltr1, ltb4, ltb4r, lt4r1, ltb4r1, mk-d-046, selective antagonist, inflammation, inflammatory disease, type 2 diabetes, g protein-coupled receptor, gpcr, flavodoxin fusion, membrane protein, lcp
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 56140.17

Authors

Michaelian, N.,Han, G.W.,Cherezov, V. (deposition date: 2020-09-07, release date: 2021-02-17, Last modification date: 2023-10-18)

• Primary citation: Michaelian, N.,Sadybekov, A.,Besserer-Offroy, E.,Han, G.W.,Krishnamurthy, H.,Zamlynny, B.A.,Fradera, X.,Siliphaivanh, P.,Presland, J.,Spencer, K.B.,Soisson, S.M.,Popov, P.,Sarret, P.,Katritch, V.,Cherezov, V.; Structural insights on ligand recognition at the human leukotriene B4 receptor 1.; Nat Commun, 12:2971-2971, 2021; PubMed: 34016973; DOI: 10.1038/s41467-021-23149-1

Experimental method

X-RAY DIFFRACTION (2.88 Å)