7K15
Crystal structure of the Human Leukotriene B4 Receptor 1 in Complex with Selective Antagonist MK-D-046
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | APS BEAMLINE 23-ID-B |
Synchrotron site | APS |
Beamline | 23-ID-B |
Temperature [K] | 123 |
Detector technology | PIXEL |
Collection date | 2018-12-14 |
Detector | DECTRIS PILATUS3 R CdTe 300K |
Wavelength(s) | 1.0332 |
Spacegroup name | P 21 2 21 |
Unit cell lengths | 70.770, 82.670, 127.480 |
Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 40.000 | 3.000 |
High resolution limit [Å] | 2.880 | 2.880 |
Rmerge | 0.246 | 1.830 |
Number of reflections | 14961 | 869 |
<I/σ(I)> | 7.48 | 0.6 |
Completeness [%] | 84.9 | 50 |
Redundancy | 8.9 | |
CC(1/2) | 0.985 | 0.314 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | LIPIDIC CUBIC PHASE | 5.8 | 293 | sodium citrate tribasic dihydrate pH 5.8, sodium acetate trihydrate, benzamidine hydrochloride, PEG-400, MK-D-046, DMSO |