2Y03

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE

Summary for 2Y03

Related1DEP 2VT4 2Y01 2Y04 2Y00 2Y02
DescriptorBETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ... (6 entities in total)
Functional Keywordsreceptor, g protein coupled receptor, seven-helix receptor, integral membrane protein, thermostabilising point mutations, gpcr, 7tm receptor
Biological sourceMELEAGRIS GALLOPAVO (TURKEY)
Cellular locationCell membrane; Multi-pass membrane protein P07700
Total number of polymer chains2
Total molecular weight75577.45
Authors
Warne, A.,Moukhametzianov, R.,Baker, J.G.,Nehme, R.,Edwards, P.C.,Leslie, A.G.W.,Schertler, G.F.X.,Tate, C.G. (deposition date: 2010-11-30, release date: 2011-01-12, Last modification date: 2011-07-13)
Primary citation
Warne, A.,Moukhametzianov, R.,Baker, J.G.,Nehme, R.,Edwards, P.C.,Leslie, A.G.W.,Schertler, G.F.X.,Tate, C.G.
The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469:241-, 2011
PubMed: 21228877 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE09746
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.85 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers50.3%4.7%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2y03
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Molmil generated image of 2y03
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Molmil generated image of 2y03
rotated about y axis by 90°
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