8BB4
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![BU of 8bb4 by Molmil](/molmil-images/mine/8bb4) | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker | 分子名称: | Elongin-B, Elongin-C, WD repeat-containing protein 5, ... | 著者 | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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8BB5
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![BU of 8bb5 by Molmil](/molmil-images/mine/8bb5) | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker | 分子名称: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | 著者 | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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8JIG
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![BU of 8jig by Molmil](/molmil-images/mine/8jig) | A Novel UHRF1-Targeted Compound | 分子名称: | E3 ubiquitin-protein ligase UHRF1, N-[2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]-N'-oxidanyl-octanediamide | 著者 | Chen, Y, Jiang, L. | 登録日 | 2023-05-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A Novel UHRF1-Targeted Compound To Be Published
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8BFM
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![BU of 8bfm by Molmil](/molmil-images/mine/8bfm) | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331 | 分子名称: | Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, pyrazolo[5,1-a]phthalazin-6-amine | 著者 | Kraemer, A, Zhu, W.F, Hernandez-Olmos, V, Proschak, E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-10-26 | 公開日 | 2022-11-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) To Be Published
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6GJM
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![BU of 6gjm by Molmil](/molmil-images/mine/6gjm) | Cyclophilin A complexed with tri-vector ligand 4. | 分子名称: | Peptidyl-prolyl cis-trans isomerase A, ethyl 2-[[(4-aminophenyl)methyl-propyl-carbamoyl]amino]ethanoate | 著者 | Georgiou, C, De Simone, A, Walkinshaw, M.D, Michel, J. | 登録日 | 2018-05-16 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.354 Å) | 主引用文献 | A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors. Chem Sci, 10, 2019
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6GS6
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![BU of 6gs6 by Molmil](/molmil-images/mine/6gs6) | Cyclophilin A single mutant D66A in complex with an inhibitor. | 分子名称: | DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase A, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate | 著者 | Georgiou, C, De Simone, A, Juarez-Jimenez, J, Walkinshaw, M.D, Michel, J. | 登録日 | 2018-06-13 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A Chem Sci, 2020
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8B6L
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![BU of 8b6l by Molmil](/molmil-images/mine/8b6l) | Subtomogram average of the human Sec61-TRAP-OSTA-translocon | 分子名称: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ... | 著者 | Gemmer, M, Fedry, J.M.M, Forster, F.G. | 登録日 | 2022-09-27 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Visualization of translation and protein biogenesis at the ER membrane. Nature, 614, 2023
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8B5B
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![BU of 8b5b by Molmil](/molmil-images/mine/8b5b) | Human BRD4 bromdomain 1 in complex with a H4 peptide containing acetyl lysine and ApmTri (H4K5acK8ApmTri) | 分子名称: | Bromodomain-containing protein 4, DI(HYDROXYETHYL)ETHER, H4K5acK8ApmTri | 著者 | Braun, M.B, Bartlick, N, Stehle, T. | 登録日 | 2022-09-22 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62, 2023
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8JNZ
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![BU of 8jnz by Molmil](/molmil-images/mine/8jnz) | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor | 分子名称: | 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | 著者 | Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. | 登録日 | 2023-06-06 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor To Be Published
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8B5C
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![BU of 8b5c by Molmil](/molmil-images/mine/8b5c) | Human BRD4 bromdomain 1 in complex with a H4 peptide containing ApmTri (H4K5/8ApmTri) | 分子名称: | Bromodomain-containing protein 4, H4K5/8ApmTri | 著者 | Braun, M.B, Bartlick, N, Stehle, T. | 登録日 | 2022-09-22 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62, 2023
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8B5A
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![BU of 8b5a by Molmil](/molmil-images/mine/8b5a) | Human BRD3 bromodomain 2 in complex with a H4 peptide containing ApmTri (H4K20ApmTri) | 分子名称: | Bromodomain-containing protein 3, H4K20ApmTri | 著者 | Braun, M.B, Bartlick, N, Stehle, T. | 登録日 | 2022-09-22 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62, 2023
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8OHD
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![BU of 8ohd by Molmil](/molmil-images/mine/8ohd) | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | 登録日 | 2023-03-21 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
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8OJ8
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![BU of 8oj8 by Molmil](/molmil-images/mine/8oj8) | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | 登録日 | 2023-03-24 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
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8B8T
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![BU of 8b8t by Molmil](/molmil-images/mine/8b8t) | Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP | 分子名称: | DNA ligase 1, Proliferating cell nuclear antigen | 著者 | Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. | 登録日 | 2022-10-05 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
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6G6R
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![BU of 6g6r by Molmil](/molmil-images/mine/6g6r) | Human Methionine Adenosyltransferase II with SAMe and PPNP | 分子名称: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Panmanee, J, Antonyuk, S.V, Hasnain, S.S. | 登録日 | 2018-04-02 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds. Febs J., 286, 2019
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8OM9
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![BU of 8om9 by Molmil](/molmil-images/mine/8om9) | MutSbeta bound to (CAG)2 DNA (open form) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | MutSbeta bound to (CAG)2 DNA (open form) To Be Published
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8OLX
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![BU of 8olx by Molmil](/molmil-images/mine/8olx) | MutSbeta bound to (CAG)2 DNA (canonical form) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein Msh2, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-30 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | MutSbeta bound to (CAG)2 DNA (canonical form) To Be Published
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8OM5
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![BU of 8om5 by Molmil](/molmil-images/mine/8om5) | DNA-free open form of MutSbeta | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | DNA-free open form of MutSbeta To Be Published
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8OMA
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![BU of 8oma by Molmil](/molmil-images/mine/8oma) | MutSbeta bound to 61bp homoduplex DNA | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | MutSbeta bound to 61bp homoduplex DNA To Be Published
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8OMO
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![BU of 8omo by Molmil](/molmil-images/mine/8omo) | DNA-unbound MutSbeta-ATP complex (bent clamp form) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | DNA-unbound MutSbeta-ATP complex (bent clamp form) To Be Published
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8OMQ
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![BU of 8omq by Molmil](/molmil-images/mine/8omq) | DNA-unbound MutSbeta-ATP complex (straight clamp form) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | 著者 | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | 登録日 | 2023-03-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | DNA-unbound MutSbeta-ATP complex (straight clamp form) To Be Published
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6GKO
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![BU of 6gko by Molmil](/molmil-images/mine/6gko) | Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... | 著者 | Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. | 登録日 | 2018-05-21 | 公開日 | 2019-06-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | 主引用文献 | Thymidylate synthase fragment screening To Be Published
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6GNJ
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![BU of 6gnj by Molmil](/molmil-images/mine/6gnj) | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101 | 分子名称: | 14-3-3 protein beta/alpha, 3-(12-oxidanylidene-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl)propanoic acid, Exoenzyme S | 著者 | Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H. | 登録日 | 2018-05-31 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface. Nat Commun, 9, 2018
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6GWS
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![BU of 6gws by Molmil](/molmil-images/mine/6gws) | Crystal structure of human PCNA in complex with three p15 peptides | 分子名称: | PCNA-associated factor, Proliferating cell nuclear antigen | 著者 | De March, M, Merino, N, Gonzalez-Magana, A, Romano-Moreno, M, Onesti, S, Blanco, F.J, De Biasio, A. | 登録日 | 2018-06-25 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | p15PAF binding to PCNA modulates the DNA sliding surface. Nucleic Acids Res., 46, 2018
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6H0F
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![BU of 6h0f by Molmil](/molmil-images/mine/6h0f) | Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) | 分子名称: | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ... | 著者 | Petzold, G, Bunker, R.D, Thoma, N.H. | 登録日 | 2018-07-09 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362, 2018
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