8B5B

Human BRD4 bromdomain 1 in complex with a H4 peptide containing acetyl lysine and ApmTri (H4K5acK8ApmTri)

Summary for 8B5B

Entry DOI	10.2210/pdb8b5b/pdb
Descriptor	Bromodomain-containing protein 4, H4K5acK8ApmTri, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	apmtri, acetyl-lysine mimic, bet-bromodomain, histone-peptide, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	48464.69
Authors	Braun, M.B.,Bartlick, N.,Stehle, T. (deposition date: 2022-09-22, release date: 2023-01-11, Last modification date: 2024-02-07)
Primary citation	Kirchgassner, S.,Braun, M.B.,Bartlick, N.,Koc, C.,Reinkemeier, C.D.,Lemke, E.A.,Stehle, T.,Schwarzer, D. Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62:e202215460-e202215460, 2023 Cited by PubMed: 36585954 DOI: 10.1002/anie.202215460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation