6H0F

Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)

Summary for 6H0F

DescriptorDNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Ikaros (IKZF1), ... (6 entities in total)
Functional Keywordse3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight604341.82
Authors
Petzold, G.,Bunker, R.D.,Thoma, N.H. (deposition date: 2018-07-09, release date: 2018-11-07, Last modification date: 2018-11-14)
Primary citation
Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H.
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362:-, 2018
PubMed: 30385546 (PDB entries with the same primary citation)
DOI: 10.1126/science.aat0572
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2500 0.9% 5.4% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6h0f
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Molmil generated image of 6h0f
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Molmil generated image of 6h0f
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