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6H0F

Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D, G, JDNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1polymer85695773.74Pfam (PF10433)
Pfam (PF03178)
UniProt (by SIFTS) (Q16531)
In PDB
Homo sapiens (Human)
2B, E, H, KProtein cereblonpolymer42648976.14UniProt (Q96SW2)
Pfam (PF02190)
Pfam (PF03226)
In PDB
Homo sapiens (Human)
3C, F, I, LDNA-binding protein Ikarospolymer384193.84UniProt (Q13422)
Pfam (PF00096)
In PDB
Homo sapiens (Human)Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1
4B, C, E, F, H...ZINC IONnon-polymer65.48Chemie (ZN)
5B, E, H, KS-Pomalidomidenon-polymer273.24Chemie (Y70)
6waterwater18.032Chemie (HOH)
Sequence modifications
A, D, G, J: -19 - 699 (PDB: 6H0F)
A, D, G, J: 706 - 1140 (PDB: 6H0F)
B, E, H, K: 36 - 442 (UniProt: Q96SW2)
PDBExternal DatabaseDetails
Met 17-initiating methionine
Asp 18-expression tag
Trp 19-expression tag
Ser 20-expression tag
His 21-expression tag
Pro 22-expression tag
Gln 23-expression tag
Phe 24-expression tag
Glu 25-expression tag
Lys 26-expression tag
Ser 27-expression tag
Ala 28-expression tag
Val 29-expression tag
Asp 30-expression tag
Glu 31-expression tag
Asn 32-expression tag
Leu 33-expression tag
Tyr 34-expression tag
Phe 35-expression tag
Gly 37Asp 37conflict
Gly 38Ser 38conflict
Gly 39Lys 39conflict
Arg 40Glu 40conflict
C, F, I, L: 141 - 174 (UniProt: Q13422)
PDBExternal DatabaseDetails
Gly 137-expression tag
Gly 138-expression tag
Gly 139-expression tag
Arg 140-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight595774.4
Non-Polymers*Number of molecules12
Total formula weight1616.2
All*Total formula weight597390.7
*Water molecules are not included.

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PDB entries from 2024-03-27

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