6H0F
Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1 | polymer | 856 | 95773.7 | 4 | Pfam (PF10433) Pfam (PF03178) UniProt (by SIFTS) (Q16531) In PDB | Homo sapiens (Human) | |
2 | B, E, H, K | Protein cereblon | polymer | 426 | 48976.1 | 4 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (Human) | |
3 | C, F, I, L | DNA-binding protein Ikaros | polymer | 38 | 4193.8 | 4 | UniProt (Q13422) Pfam (PF00096) In PDB | Homo sapiens (Human) | Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1 |
4 | B, C, E, F, H... | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
5 | B, E, H, K | S-Pomalidomide | non-polymer | 273.2 | 4 | Chemie (Y70) | |||
6 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, D, G, J: -19 - 699 (PDB: 6H0F)
A, D, G, J: 706 - 1140 (PDB: 6H0F)
B, E, H, K: 36 - 442 (UniProt: Q96SW2)
C, F, I, L: 141 - 174 (UniProt: Q13422)
A, D, G, J: 706 - 1140 (PDB: 6H0F)
B, E, H, K: 36 - 442 (UniProt: Q96SW2)
PDB | External Database | Details |
---|---|---|
Met 17 | - | initiating methionine |
Asp 18 | - | expression tag |
Trp 19 | - | expression tag |
Ser 20 | - | expression tag |
His 21 | - | expression tag |
Pro 22 | - | expression tag |
Gln 23 | - | expression tag |
Phe 24 | - | expression tag |
Glu 25 | - | expression tag |
Lys 26 | - | expression tag |
Ser 27 | - | expression tag |
Ala 28 | - | expression tag |
Val 29 | - | expression tag |
Asp 30 | - | expression tag |
Glu 31 | - | expression tag |
Asn 32 | - | expression tag |
Leu 33 | - | expression tag |
Tyr 34 | - | expression tag |
Phe 35 | - | expression tag |
Gly 37 | Asp 37 | conflict |
Gly 38 | Ser 38 | conflict |
Gly 39 | Lys 39 | conflict |
Arg 40 | Glu 40 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 137 | - | expression tag |
Gly 138 | - | expression tag |
Gly 139 | - | expression tag |
Arg 140 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 595774.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1616.2 | |
All* | Total formula weight | 597390.7 |