8BB5

Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker

Summary for 8BB5

Entry DOI	10.2210/pdb8bb5/pdb
Related	7q2j
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (9 entities in total)
Functional Keywords	e3-ligase, wdr5, vhl, elongin, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	78719.68
Authors	Kraemer, A.,Doelle, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-10-12, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Schwalm, M.P.,Kramer, A.,Dolle, A.,Weckesser, J.,Yu, X.,Jin, J.,Saxena, K.,Knapp, S. Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30:753-765.e8, 2023 Cited by PubMed: 37354907 DOI: 10.1016/j.chembiol.2023.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation