8BB5
Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (B) | Elongin-C | polymer | 98 | 11043.7 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (C) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | D (D) | WD repeat-containing protein 5 | polymer | 321 | 35296.9 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | BMP2-induced 3-kb gene protein |
| 5 | E, F, G, K, L... (A, C, D) | THIOCYANATE ION | non-polymer | 58.1 | 10 | Chemie (SCN) | |||
| 6 | H (C) | ~{N}-[5-[4-[[4-[2-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-2-oxidanylidene-ethyl]phenyl]methylcarbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanyl-4-(trifluoromethyl)pyridine-3-carboxamide | non-polymer | 1060.2 | 1 | Chemie (Q43) | |||
| 7 | I, Q, R, T (C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 8 | J (C) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 9 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 334 | Chemie (HOH) |
Sequence modifications
B: 16 - 112 (UniProt: Q15369)
C: 54 - 213 (UniProt: P40337)
D: 33 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Lys 15 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 14 | - | initiating methionine |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Leu 27 | - | expression tag |
| Val 28 | - | expression tag |
| Pro 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76791.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1928.4 | |
| All* | Total formula weight | 78719.7 |
