8BB4
Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker
Summary for 8BB4
Entry DOI | 10.2210/pdb8bb4/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (6 entities in total) |
Functional Keywords | e3-ligase, wdr5, vhl, elongin, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 77789.42 |
Authors | Kraemer, A.,Doelle, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-10-12, release date: 2022-11-09, Last modification date: 2024-01-31) |
Primary citation | Schwalm, M.P.,Kramer, A.,Dolle, A.,Weckesser, J.,Yu, X.,Jin, J.,Saxena, K.,Knapp, S. Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30:753-765.e8, 2023 Cited by PubMed: 37354907DOI: 10.1016/j.chembiol.2023.06.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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