8BB4

Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0030891	cellular_component	VCB complex
I	0070449	cellular_component	elongin complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000123	cellular_component	histone acetyltransferase complex
Q	0001501	biological_process	skeletal system development
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0006094	biological_process	gluconeogenesis
Q	0006325	biological_process	chromatin organization
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0035064	molecular_function	methylated histone binding
Q	0035097	cellular_component	histone methyltransferase complex
Q	0042393	molecular_function	histone binding
Q	0042800	molecular_function	histone H3K4 methyltransferase activity
Q	0044545	cellular_component	NSL complex
Q	0044665	cellular_component	MLL1/2 complex
Q	0044666	cellular_component	MLL3/4 complex
Q	0045722	biological_process	positive regulation of gluconeogenesis
Q	0045815	biological_process	transcription initiation-coupled chromatin remodeling
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0045995	biological_process	regulation of embryonic development
Q	0048188	cellular_component	Set1C/COMPASS complex
Q	0051302	biological_process	regulation of cell division
Q	0051726	biological_process	regulation of cell cycle
Q	0071339	cellular_component	MLL1 complex
Q	0072686	cellular_component	mitotic spindle
Q	0090043	biological_process	regulation of tubulin deacetylation
Q	0140672	cellular_component	ATAC complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
Q	LEU102-VAL116
Q	ILE144-VAL158
Q	ILE186-THR200
Q	ILE274-LEU288

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with histone H3

Chain	Residue	Details
Q	ASP107
Q	PHE133
Q	PHE263
Q	GLU322

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
Q	LYS112

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
Q	LYS46

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