8B5C

Human BRD4 bromdomain 1 in complex with a H4 peptide containing ApmTri (H4K5/8ApmTri)

Summary for 8B5C

• Entry DOI: 10.2210/pdb8b5c/pdb
• Descriptor: Bromodomain-containing protein 4, H4K5/8ApmTri (3 entities in total)
• Functional Keywords: apmtri, acetyl-lysine mimic, bet-bromodomain, histone-peptide, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 16556.02

Authors

Braun, M.B.,Bartlick, N.,Stehle, T. (deposition date: 2022-09-22, release date: 2023-01-11, Last modification date: 2024-02-07)

• Primary citation: Kirchgassner, S.,Braun, M.B.,Bartlick, N.,Koc, C.,Reinkemeier, C.D.,Lemke, E.A.,Stehle, T.,Schwarzer, D.; Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family.; Angew.Chem.Int.Ed.Engl., 62:e202215460-e202215460, 2023; PubMed: 36585954; DOI: 10.1002/anie.202215460

Experimental method

X-RAY DIFFRACTION (1.58 Å)