6F6Z
| Mouse Thymidylate Synthase Cocrystallized with N(4)OHdCMP and Soaked in Methylenetetrahydrofolate | Descriptor: | (2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), Thymidylate synthase | Authors: | Wilk, P, Jarmula, A, Maj, P, Rode, W. | Deposit date: | 2017-12-06 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.127 Å) | Cite: | Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies Int J Mol Sci, 22, 2021
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5M4Z
| Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate | Descriptor: | GLYCEROL, Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Wilk, P, Maj, P, Jarmula, A, Dowiercial, A, Rode, W. | Deposit date: | 2016-10-19 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.179 Å) | Cite: | Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies. Int J Mol Sci, 22, 2021
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5M4Q
| Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | Descriptor: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5MBY
| Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | Authors: | Wilk, P, Piwowarczyk, R, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC1
| Crystal Structure of Asp276Asn mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | Authors: | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MBZ
| Crystal Structure of Ser202Phe mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | Authors: | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC5
| Crystal Structure of delGlu452 mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | Authors: | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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6QSC
| Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | Authors: | Wilk, P, Wator, E, Weiss, M.S. | Deposit date: | 2019-02-20 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.569 Å) | Cite: | Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing. Genet Mol Biol, 44, 2021
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6QSB
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4PSG
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7B9P
| Structure of Ribonucleotide reductase from Rhodobacter sphaeroides | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase | Authors: | Wilk, P, Feiler, C, Loderer, C, Kabinger, F. | Deposit date: | 2020-12-14 | Release date: | 2022-01-12 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.646 Å) | Cite: | HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase. Biochemistry, 61, 2022
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5M4J
| Crystal Structure of Wild-Type Human Prolidase with GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, PROLINE, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5M4L
| Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | Descriptor: | GLYCEROL, HYDROXIDE ION, LEUCINE, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5M4G
| Crystal Structure of Wild-Type Human Prolidase with Mn ions | Descriptor: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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6ZQ5
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in P2221 space group | Descriptor: | 1,2-ETHANEDIOL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ8
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in P3221 space group | Descriptor: | Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Tokarz, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ4
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6ZQ7
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in I222 space group | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ6
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5NOO
| Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | Authors: | Wilk, P, Jarmula, A, Maj, P, Dowiercial, A, Banaszak, K, Rypniewski, W, Rode, W. | Deposit date: | 2017-04-12 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77, 2017
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6H2Q
| Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and LeuPro ligand | Descriptor: | GLYCEROL, LEUCINE, MANGANESE (II) ION, ... | Authors: | Wilk, P, Piwowarczyk, R, Weiss, M.S. | Deposit date: | 2018-07-14 | Release date: | 2018-08-15 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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6H2P
| Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and Cacodylate ligand | Descriptor: | CACODYLATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Wilk, P, Piwowarczyk, R, Weiss, M.S. | Deposit date: | 2018-07-14 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.479 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC3
| Crystal Structure of Glu412Lys mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | Authors: | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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7PQF
| Crystal structure of Campylobacter jejuni DsbA2 | Descriptor: | Thiol:disulfide interchange protein DsbA/DsbL | Authors: | Wilk, P, Banas, A.M, Bocian-Ostrzycka, K.M, Jagusztyn-Krynicka, E.K. | Deposit date: | 2021-09-17 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Interplay between DsbA1, DsbA2 and C8J_1298 Periplasmic Oxidoreductases of Campylobacter jejuni and Their Impact on Bacterial Physiology and Pathogenesis. Int J Mol Sci, 22, 2021
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5MC4
| Crystal Structure of Gly448Arg mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | Authors: | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | Deposit date: | 2016-11-09 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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