PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

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1H4L	Structure and regulation of the CDK5-p25(nck5a) complex 分子名称: CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 著者 Tarricone, C, Dhavan, R, Peng, J, Areces, L.B, Tsai, L.-H, Musacchio, A. 登録日 2001-05-11 公開日 2002-08-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure and Regulation of the Cdk5-P25(Nck5A) Complex Mol.Cell, 8, 2001
1H24	CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
1F5Q	CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2 分子名称: CHLORIDE ION, CYCLIN DEPENDENT KINASE 2, GAMMA HERPESVIRUS CYCLIN 著者 Card, G.L, Knowles, P, Laman, H, Jones, N, McDonald, N.Q. 登録日 2000-06-15 公開日 2000-12-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of a gamma-herpesvirus cyclin-cdk complex. EMBO J., 19, 2000
1H28	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
7P1L	The MARK3 Kinase Domain Bound To AA-CS-1-008 分子名称: 1,2-ETHANEDIOL, 5-Bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine, MAP/microtubule affinity-regulating kinase 3 著者 Dederer, V, Preuss, F, Chatterjee, D, Vlassova, A, Mathea, S, Axtman, A, Knapp, S. 登録日 2021-07-01 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J.Med.Chem., 65, 2022
7JHG	Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7JHH	Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7JIJ	ATP-bound AMP-activated protein kinase 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Powell, K, Xu, T, Brunzelle, J.S, Xu, H.X, Melcher, K. 登録日 2020-07-23 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
7P5Z	Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 7, ... 著者 Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. 登録日 2021-07-15 公開日 2022-02-02 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
7PWD	Structure of an inhibited GRK2-G-beta and G-gamma complex 分子名称: 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ... 著者 Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M. 登録日 2021-10-06 公開日 2021-10-20 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022
7PUE	Human serum and glucocorticoid-regulated kinase 1 in complex with pyrazolopyridine inhibitor 3a 分子名称: 6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, GLYCEROL, Serine/threonine-protein kinase Sgk1 著者 Dreyer, M.K, Halland, N, Nazare, M. 登録日 2021-09-29 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J.Med.Chem., 65, 2022
7JUQ	Crystal Structure of KSR2:MEK1 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUR	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUX	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7PT7	Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 7, ... 著者 Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. 登録日 2021-09-26 公開日 2022-06-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nat Commun, 13, 2022
7PT6	Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... 著者 Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. 登録日 2021-09-26 公開日 2022-06-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nat Commun, 13, 2022
7Q52	Crystal structure of S/T protein kinase PknG from Mycobacterium tuberculosis in complex with inhibitor L2W 分子名称: 2-azanyl-3-(4-fluorophenyl)carbonyl-indolizine-1-carboxamide, FE (III) ION, SODIUM ION, ... 著者 Defelipe, L.A, Burastero, O, Bento, I, Garcia-Alai, M.M. 登録日 2021-11-02 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors. J.Med.Chem., 65, 2022
7JUV	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUT	Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7K7L	Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure 分子名称: 3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Spurlino, J.C, Milligan, C. 登録日 2020-09-23 公開日 2020-10-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.539 Å) 主引用文献 Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg.Med.Chem.Lett., 30, 2020
7JUS	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7K7Z	Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure 分子名称: 3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Spurlino, J.C, Milligan, C. 登録日 2020-09-24 公開日 2020-10-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.606087 Å) 主引用文献 Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg.Med.Chem.Lett., 30, 2020
7JV0	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUW	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV1	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.62 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020

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