Summary for 7P1L
| Entry DOI | 10.2210/pdb7p1l/pdb |
| Descriptor | MAP/microtubule affinity-regulating kinase 3, 5-Bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | kinase inhibitor active site folded activation loop uba domain, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 76500.09 |
| Authors | Dederer, V.,Preuss, F.,Chatterjee, D.,Vlassova, A.,Mathea, S.,Axtman, A.,Knapp, S. (deposition date: 2021-07-01, release date: 2021-07-14, Last modification date: 2024-01-31) |
| Primary citation | Drewry, D.H.,Annor-Gyamfi, J.K.,Wells, C.I.,Pickett, J.E.,Dederer, V.,Preuss, F.,Mathea, S.,Axtman, A.D. Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J.Med.Chem., 65:1313-1328, 2022 Cited by PubMed: 34333981DOI: 10.1021/acs.jmedchem.1c00440 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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