7JUV

Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1

Summary for 7JUV

• Entry DOI: 10.2210/pdb7juv/pdb
• Related: 7JUQ 7JUR 7JUS 7JUT 7JUU 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
• Descriptor: Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• Functional Keywords: kinase, pseudokinase, drug target, cell signaling and cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 84595.57

Authors

Khan, Z.M.,Dar, A.C.,Scopton, A.P. (deposition date: 2020-08-20, release date: 2020-09-30, Last modification date: 2023-10-18)

• Primary citation: Khan, Z.M.,Real, A.M.,Marsiglia, W.M.,Chow, A.,Duffy, M.E.,Yerabolu, J.R.,Scopton, A.P.,Dar, A.C.; Structural basis for the action of the drug trametinib at KSR-bound MEK.; Nature, 588:509-514, 2020; PubMed: 32927473; DOI: 10.1038/s41586-020-2760-4

Experimental method

X-RAY DIFFRACTION (3.36 Å)