Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7JUR

Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib

Summary for 7JUR
Entry DOI10.2210/pdb7jur/pdb
Related7JUQ 7JUS 7JUT 7JUU 7JUV 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
DescriptorKinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
Functional Keywordskinase, pseudokinase, drug target, cell signaling and cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight84544.50
Authors
Khan, Z.M.,Dar, A.C. (deposition date: 2020-08-20, release date: 2020-09-30, Last modification date: 2023-10-18)
Primary citationKhan, Z.M.,Real, A.M.,Marsiglia, W.M.,Chow, A.,Duffy, M.E.,Yerabolu, J.R.,Scopton, A.P.,Dar, A.C.
Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588:509-514, 2020
Cited by
PubMed: 32927473
DOI: 10.1038/s41586-020-2760-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.82 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon