7JUT

Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib

Summary for 7JUT

Entry DOI	10.2210/pdb7jut/pdb
Related	7JUQ 7JUR 7JUS 7JUU 7JUV 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
Descriptor	Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	kinase, pseudokinase, drug target, cell signaling and cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	84338.17
Authors	Khan, Z.M.,Dar, A.C. (deposition date: 2020-08-20, release date: 2020-09-30, Last modification date: 2023-10-18)
Primary citation	Khan, Z.M.,Real, A.M.,Marsiglia, W.M.,Chow, A.,Duffy, M.E.,Yerabolu, J.R.,Scopton, A.P.,Dar, A.C. Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588:509-514, 2020 Cited by PubMed: 32927473 DOI: 10.1038/s41586-020-2760-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.09 Å)

Structure validation