PDB: 377 件ウェブページステータス検索Chemie searchBIRD

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7P9N	Crystal structure of CD73 in complex with AMP in the open form 分子名称: 5'-nucleotidase, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-07-27 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7P9R	Crystal structure of CD73 in complex with GMP in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, GLYCEROL, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-07-27 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PCP	Crystal structure of CD73 in complex with 5-iodouracil in the open form 分子名称: 5'-nucleotidase, 5-IODOURACIL, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-03 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PBY	Crystal structure of CD73 in complex with 4-nitrocatechol in the open form 分子名称: 4-NITROCATECHOL, 5'-nucleotidase, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-02 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-04 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PKS	Structural basis of Integrator-mediated transcription regulation 分子名称: DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... 著者 Fianu, I, Chen, Y, Dienemann, C, Cramer, P. 登録日 2021-08-26 公開日 2021-12-08 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of Integrator-mediated transcription regulation. Science, 374, 2021
7QGM	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4598 (a 3-methyl-CMPCP derivative, compound 16 in paper) in the closed state (crystal form III) 分子名称: 5'-nucleotidase, CALCIUM ION, ZINC ION, ... 著者 Strater, N. 登録日 2021-12-08 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
7QGL	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the open state 分子名称: 5'-nucleotidase, CALCIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Strater, N. 登録日 2021-12-08 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
7QGO	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the closed state (crystal form III) 分子名称: 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[(4~{E})-4-[(4-methoxycarbonylphenyl)methoxyimino]-3-methyl-2-oxidanylidene-pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid 著者 Strater, N. 登録日 2021-12-09 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.206 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
7QGA	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4598 (a 3-methyl-CMPCP derivative, compound 16 in paper) in the open state 分子名称: 5'-nucleotidase, CALCIUM ION, TETRAETHYLENE GLYCOL, ... 著者 Strater, N. 登録日 2021-12-07 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
7UPI	Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex 分子名称: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... 著者 Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. 登録日 2022-04-15 公開日 2022-05-04 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
8GAE	Hsp90 provides platform for CRaf dephosphorylation by PP5 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... 著者 Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. 登録日 2023-02-22 公開日 2023-04-26 最終更新日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8GFT	Hsp90 provides platform for CRaf dephosphorylation by PP5 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... 著者 Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. 登録日 2023-03-08 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8B5R	p97-p37-SPI substrate complex 分子名称: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... 著者 van den Boom, J, Marini, G, Meyer, H, Saibil, H. 登録日 2022-09-24 公開日 2023-06-07 最終更新日 2023-07-26 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
7N6G	C1 of central pair 分子名称: CPC1, Calmodulin, DPY30, ... 著者 Han, L, Zhang, K. 登録日 2021-06-08 公開日 2022-05-18 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022
7NZM	Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yan, Y, Hardwick, S, Ron, D. 登録日 2021-03-24 公開日 2021-09-29 最終更新日 2021-10-20 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
4V0U	The crystal structure of ternary PP1G-PPP1R15B and G-actin complex 分子名称: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. 登録日 2014-09-18 公開日 2015-03-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (7.88 Å) 主引用文献 G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
7TVF	Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom 分子名称: CHLORIDE ION, GLYCEROL, Leucine-rich repeat protein SHOC-2, ... 著者 Bonsor, D.A, Simanshu, D.K. 登録日 2022-02-04 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat.Struct.Mol.Biol., 29, 2022
7TXH	Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca 分子名称: GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... 著者 Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. 登録日 2022-02-09 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature, 609, 2022
7SD0	Cryo-EM structure of the SHOC2:PP1C:MRAS complex 分子名称: Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... 著者 Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. 登録日 2021-09-29 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis for SHOC2 modulation of RAS signalling. Nature, 609, 2022
7SQC	Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii 分子名称: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... 著者 Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. 登録日 2021-11-05 公開日 2022-04-13 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat.Struct.Mol.Biol., 29, 2022
7ZR5	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... 著者 Oberoi, J, Pearl, L.H. 登録日 2022-05-03 公開日 2022-12-14 最終更新日 2022-12-21 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
7ZR6	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... 著者 Oberoi, J, Pearl, L.H. 登録日 2022-05-03 公開日 2022-12-28 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
7YCX	The structure of INTAC-PEC complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... 著者 Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. 登録日 2022-07-02 公開日 2023-03-15 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (4.18 Å) 主引用文献 Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
4IL1	Crystal Structure of the Rat Calcineurin 分子名称: CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... 著者 Ye, Q, Faucher, F, Jia, Z. 登録日 2012-12-28 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of calcineurin activation by calmodulin. Cell Signal, 25, 2013

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