5I8R
 
 | | aSMase with zinc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-19 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.646 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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3H66
 | | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms | | 分子名称: | Serine/threonine-protein phosphatase 5, ZINC ION | | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | | 登録日 | 2009-04-23 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
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3H61
 | | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms originally soaked with norcantharidin (which is present in the structure in the hydrolyzed form) | | 分子名称: | (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | | 登録日 | 2009-04-23 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
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3H60
 | | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Mn2+ atoms | | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | | 登録日 | 2009-04-23 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
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3H63
 | | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form) | | 分子名称: | (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | | 登録日 | 2009-04-23 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
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5IOH
 | | RepoMan-PP1a (protein phosphatase 1, alpha isoform) holoenzyme complex | | 分子名称: | Cell division cycle-associated protein 2, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | | 著者 | Kumar, G.S, Peti, W, Page, R. | | 登録日 | 2016-03-08 | | 公開日 | 2016-10-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.566 Å) | | 主引用文献 | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
Elife, 5, 2016
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5I85
 | | aSMase with zinc and phosphocholine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-18 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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5I81
 | | aSMase with zinc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-18 | | 公開日 | 2016-09-07 | | 最終更新日 | 2021-03-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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3IVD
 | | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine | | 分子名称: | CHLORIDE ION, FE (III) ION, MANGANESE (II) ION, ... | | 著者 | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-08-31 | | 公開日 | 2009-09-29 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine
To be Published
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3IVE
 | | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine | | 分子名称: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CHLORIDE ION, FE (III) ION, ... | | 著者 | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-08-31 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine
To be Published
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7SD0
 | | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | | 著者 | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | | 登録日 | 2021-09-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
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7N6G
 | | C1 of central pair | | 分子名称: | CPC1, Calmodulin, DPY30, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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8GAE
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | 著者 | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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8GFT
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | 著者 | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | 登録日 | 2023-03-08 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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4V0U
 | | The crystal structure of ternary PP1G-PPP1R15B and G-actin complex | | 分子名称: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | | 登録日 | 2014-09-18 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (7.88 Å) | | 主引用文献 | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
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7YCX
 | | The structure of INTAC-PEC complex | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | | 登録日 | 2022-07-02 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | | 主引用文献 | Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
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7ZR5
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7ZR6
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8B5R
 | | p97-p37-SPI substrate complex | | 分子名称: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | | 著者 | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | | 登録日 | 2022-09-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
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7SQC
 | | Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... | | 著者 | Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. | | 登録日 | 2021-11-05 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
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4IL1
 | | Crystal Structure of the Rat Calcineurin | | 分子名称: | CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... | | 著者 | Ye, Q, Faucher, F, Jia, Z. | | 登録日 | 2012-12-28 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of calcineurin activation by calmodulin.
Cell Signal, 25, 2013
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7TVF
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7TXH
 | | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | | 分子名称: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | | 著者 | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | | 登録日 | 2022-02-09 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature, 609, 2022
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7UPI
 | | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | | 分子名称: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | | 著者 | Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. | | 登録日 | 2022-04-15 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Nature, 609, 2022
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6GHM
 | | Structure of PP1 alpha phosphatase bound to ASPP2 | | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ... | | 著者 | Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y. | | 登録日 | 2018-05-08 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.
Nat Commun, 10, 2019
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