4EDI
 
 | | Disulfide bonded EutL from Clostridium perfringens | | 分子名称: | Ethanolamine utilization protein, SODIUM ION | | 著者 | Thompson, M.C, Cascio, D, Crowley, C.S, Kopstein, J.S, Yeates, T.O. | | 登録日 | 2012-03-27 | | 公開日 | 2013-03-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | | 主引用文献 | An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein.
Protein Sci., 24, 2015
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5B56
 | | Crystal structure of HIV-1 VPR C-Terminal domain and DIBB-M-Importin-Alpha2 complex | | 分子名称: | Importin subunit alpha-1, Protein Vpr | | 著者 | Miyatake, H, Sanjoh, A, Matusda, G, Murakami, T, Murakami, H, Hagiwara, K, Yokoyama, M, Sato, H, Miyamoto, Y, Dohmae, N, Aida, Y. | | 登録日 | 2016-04-25 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha
J.Mol.Biol., 428, 2016
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3AB4
 | | Crystal structure of feedback inhibition resistant mutant of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine | | 分子名称: | Aspartokinase, LYSINE, THREONINE | | 著者 | Yoshida, A, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2009-11-30 | | 公開日 | 2010-06-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum
J.Biol.Chem., 285, 2010
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4EE7
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3U0U
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4E45
 | | Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM | | 分子名称: | Centromere protein S, Centromere protein X, Fanconi anemia group M protein, ... | | 著者 | Fox III, D, Zhao, Y, Yang, W, Weidong, W. | | 登録日 | 2012-03-12 | | 公開日 | 2013-03-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published
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5AP3
 | | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE, ... | | 著者 | Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. | | 登録日 | 2015-09-14 | | 公開日 | 2015-09-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Cancer Res., 75, 2015
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3TK2
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3AOD
 | | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, RIFAMPICIN | | 著者 | Nakashima, R, Sakurai, K, Yamaguchi, A. | | 登録日 | 2010-09-23 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nature, 480, 2011
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5BKC
 | | Crystal structure of AAD-1 in complex with (R)-diclofop, Mn(II), and 2-oxoglutarate | | 分子名称: | (2R)-2-{4-[(3,5-dichloropyridin-2-yl)oxy]phenoxy}propanoic acid, (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, 2-OXOGLUTARIC ACID, ... | | 著者 | Chekan, J.R, Nair, S.K. | | 登録日 | 2019-06-02 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants.
Proc.Natl.Acad.Sci.USA, 116, 2019
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3TKM
 | | Crystal structure PPAR delta binding GW0742 | | 分子名称: | GLYCEROL, Peroxisome proliferator-activated receptor delta, {4-[({2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid | | 著者 | Trivella, D.B.B, Batista, F.H, Polikarpov, I. | | 登録日 | 2011-08-27 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding.
Plos One, 7, 2012
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4EMP
 | | Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Ye, F, Zhang, J, Liu, H, Luo, C, Yang, C.-G. | | 登録日 | 2012-04-12 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease
J.Biol.Chem., 288, 2013
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5BMM
 | | Src in complex with DNA-templated macrocyclic inhibitor MC25b | | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC25b | | 著者 | Georghiou, G, Guja, K.E, Aleem, S, Kleiner, R.E, Liu, D.R, Miller, W.T, Garcia-Diaz, M, Seeliger, M.A. | | 登録日 | 2015-05-22 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.
Cell Chem Biol, 23, 2016
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4E4V
 | | The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Importin subunit alpha-2 | | 著者 | Hang, P.C, Miknis, Z.M, Franke, W.A, Umland, T.C, Schultz, L.W. | | 登録日 | 2012-03-13 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5283 Å) | | 主引用文献 | The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
To be Published
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4OE4
 | | Crystal Structure of Yeast ALDH4A1 Complexed with NAD+ | | 分子名称: | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Tanner, J.J. | | 登録日 | 2014-01-11 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.168 Å) | | 主引用文献 | Structural Studies of Yeast Delta (1)-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State.
Biochemistry, 53, 2014
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3A71
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4ENH
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3U2N
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4EO5
 | | Yeast Asf1 bound to H3/H4G94P mutant | | 分子名称: | ACETATE ION, GLYCEROL, Histone H3.2, ... | | 著者 | Scorgie, J.K, Churchill, M.E. | | 登録日 | 2012-04-13 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability.
Epigenetics Chromatin, 5, 2012
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3TM2
 | | Crystal structure of mature ThnT with a covalently bound product mimic | | 分子名称: | (2R)-N-(4-chloro-3-oxobutyl)-2,4-dihydroxy-3,3-dimethylbutanamide, cysteine transferase | | 著者 | Schildbach, J.F, Wright, N.T, Buller, A.R. | | 登録日 | 2011-08-30 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
J.Mol.Biol., 422, 2012
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3TN5
 | | Crystal structure of GkaP mutant Y99L from Geobacillus kaustophilus HTA426 | | 分子名称: | COBALT (II) ION, PHOSPHATE ION, Phosphotriesterase | | 著者 | An, J, Zhang, Z, Zhang, Y, Feng, Y, Wu, G. | | 登録日 | 2011-09-01 | | 公開日 | 2012-09-12 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides
to be published
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4OSI
 | | Crystal structure of the TAL effector dHax3 with NI RVD at 2.8 angstrom resolution | | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 | | 著者 | Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. | | 登録日 | 2014-02-13 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.849 Å) | | 主引用文献 | Revisiting the TALE repeat
Protein Cell, 5, 2014
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4OT1
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3U5K
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam | | 分子名称: | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, Bromodomain-containing protein 4 | | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2011-10-11 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
Bioorg.Med.Chem., 20, 2012
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1NVM
 | | Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-hydroxy-2-oxovalerate aldolase, MANGANESE (II) ION, ... | | 著者 | Manjasetty, A.B, Powlowski, J, Vrielink, A. | | 登録日 | 2003-02-04 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a
reactive and volatile intermediate
Proc.Natl.Acad.Sci.USA, 100, 2003
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