3U5K
Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam
Summary for 3U5K
| Entry DOI | 10.2210/pdb3u5k/pdb |
| Related | 3U5J 3U5L |
| Descriptor | Bromodomain-containing protein 4, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (3 entities in total) |
| Functional Keywords | bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, structural genomics consortium, sgc, signaling protein-inhibitor complex, signaling protein/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (By similarity): O60885 |
| Total number of polymer chains | 4 |
| Total formula weight | 61700.59 |
| Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-10-11, release date: 2011-11-23, Last modification date: 2023-09-13) |
| Primary citation | Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Keller, M.,Wrobel, M.,Morgenstern, O.,Bracher, F.,Knapp, S. Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20:1878-1886, 2012 Cited by PubMed: 22137933DOI: 10.1016/j.bmc.2011.10.080 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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