3U5K
Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 4 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
| 2 | A, B, C, D | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine | non-polymer | 325.8 | 4 | Chemie (08J) | |||
| 3 | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 42 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60397.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1303.1 | |
| All* | Total formula weight | 61700.6 |
