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3U5K

Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam

Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 08J A 1
ChainResidue
AHOH5
AHOH187
ATRP81
APRO82
AVAL87
ALEU92
ALEU94
AASN140
AILE146
AHOH169

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 08J B 2
ChainResidue
BTRP81
BPRO82
BLEU92
BLEU94
BASN140
BILE146
BHOH169
BHOH231
BHOH232

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 08J C 3
ChainResidue
CHOH28
CTRP81
CPRO82
CVAL87
CLEU92
CASN140
CILE146
CMET149
CHOH199

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 08J D 4
ChainResidue
DTRP81
DPRO82
DPHE83
DLEU92
DLEU94
DASN140
DILE146
DMET149

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues424
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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