4ENH
Crystal Structure of Human Cytochrome P450 CYP46A1 with Fluvoxamine Bound
Summary for 4ENH
Entry DOI | 10.2210/pdb4enh/pdb |
Related | 2Q9F 2Q9G 3MDM 3MDR 3MDT 3MDV |
Descriptor | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, Fluvoxamine, ... (4 entities in total) |
Functional Keywords | enzyme, p450, fluvoxamine, oxidoreductase, endoplasmic reticulum |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2 |
Total number of polymer chains | 1 |
Total formula weight | 53059.91 |
Authors | Stout, C.D.,Mast, N.,Pikuleva, I.A. (deposition date: 2012-04-13, release date: 2012-08-22, Last modification date: 2023-09-13) |
Primary citation | Mast, N.,Linger, M.,Clark, M.,Wiseman, J.,Stout, C.D.,Pikuleva, I.A. In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine. Mol.Pharmacol., 82:824-834, 2012 Cited by PubMed: 22859721DOI: 10.1124/mol.112.080424 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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