3AB4

Crystal structure of feedback inhibition resistant mutant of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine

Summary for 3AB4

• Entry DOI: 10.2210/pdb3ab4/pdb
• Related: 2DTJ 3AAW 3AB2
• Descriptor: Aspartokinase, THREONINE, LYSINE, ... (5 entities in total)
• Functional Keywords: aspartate kinase, concerted inhibition, alternative initiation, amino-acid biosynthesis, atp-binding, diaminopimelate biosynthesis, kinase, lysine biosynthesis, nucleotide-binding, transferase
• Biological source: Corynebacterium glutamicum (Brevibacterium flavum); More
• Total number of polymer chains: 16
• Total formula weight: 517364.02

Authors

Yoshida, A.,Tomita, T.,Kuzuyama, T.,Nishiyama, M. (deposition date: 2009-11-30, release date: 2010-06-23, Last modification date: 2023-11-01)

• Primary citation: Yoshida, A.,Tomita, T.,Kuzuyama, T.,Nishiyama, M.; Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum; J.Biol.Chem., 285:27477-27486, 2010; PubMed: 20573952; DOI: 10.1074/jbc.M110.111153

Experimental method

X-RAY DIFFRACTION (2.47 Å)