3AB4
Crystal structure of feedback inhibition resistant mutant of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004072 | molecular_function | aspartate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009085 | biological_process | lysine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
A | 0009090 | biological_process | homoserine biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0019877 | biological_process | diaminopimelate biosynthetic process |
C | 0004072 | molecular_function | aspartate kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0009085 | biological_process | lysine biosynthetic process |
C | 0009088 | biological_process | threonine biosynthetic process |
C | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
C | 0009090 | biological_process | homoserine biosynthetic process |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0019877 | biological_process | diaminopimelate biosynthetic process |
E | 0004072 | molecular_function | aspartate kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0005829 | cellular_component | cytosol |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0009085 | biological_process | lysine biosynthetic process |
E | 0009088 | biological_process | threonine biosynthetic process |
E | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
E | 0009090 | biological_process | homoserine biosynthetic process |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0019877 | biological_process | diaminopimelate biosynthetic process |
G | 0004072 | molecular_function | aspartate kinase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0005829 | cellular_component | cytosol |
G | 0008652 | biological_process | amino acid biosynthetic process |
G | 0009085 | biological_process | lysine biosynthetic process |
G | 0009088 | biological_process | threonine biosynthetic process |
G | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
G | 0009090 | biological_process | homoserine biosynthetic process |
G | 0016301 | molecular_function | kinase activity |
G | 0016310 | biological_process | phosphorylation |
G | 0019877 | biological_process | diaminopimelate biosynthetic process |
I | 0004072 | molecular_function | aspartate kinase activity |
I | 0005524 | molecular_function | ATP binding |
I | 0005829 | cellular_component | cytosol |
I | 0008652 | biological_process | amino acid biosynthetic process |
I | 0009085 | biological_process | lysine biosynthetic process |
I | 0009088 | biological_process | threonine biosynthetic process |
I | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
I | 0009090 | biological_process | homoserine biosynthetic process |
I | 0016301 | molecular_function | kinase activity |
I | 0016310 | biological_process | phosphorylation |
I | 0019877 | biological_process | diaminopimelate biosynthetic process |
K | 0004072 | molecular_function | aspartate kinase activity |
K | 0005524 | molecular_function | ATP binding |
K | 0005829 | cellular_component | cytosol |
K | 0008652 | biological_process | amino acid biosynthetic process |
K | 0009085 | biological_process | lysine biosynthetic process |
K | 0009088 | biological_process | threonine biosynthetic process |
K | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
K | 0009090 | biological_process | homoserine biosynthetic process |
K | 0016301 | molecular_function | kinase activity |
K | 0016310 | biological_process | phosphorylation |
K | 0019877 | biological_process | diaminopimelate biosynthetic process |
M | 0004072 | molecular_function | aspartate kinase activity |
M | 0005524 | molecular_function | ATP binding |
M | 0005829 | cellular_component | cytosol |
M | 0008652 | biological_process | amino acid biosynthetic process |
M | 0009085 | biological_process | lysine biosynthetic process |
M | 0009088 | biological_process | threonine biosynthetic process |
M | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
M | 0009090 | biological_process | homoserine biosynthetic process |
M | 0016301 | molecular_function | kinase activity |
M | 0016310 | biological_process | phosphorylation |
M | 0019877 | biological_process | diaminopimelate biosynthetic process |
O | 0004072 | molecular_function | aspartate kinase activity |
O | 0005524 | molecular_function | ATP binding |
O | 0005829 | cellular_component | cytosol |
O | 0008652 | biological_process | amino acid biosynthetic process |
O | 0009085 | biological_process | lysine biosynthetic process |
O | 0009088 | biological_process | threonine biosynthetic process |
O | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
O | 0009090 | biological_process | homoserine biosynthetic process |
O | 0016301 | molecular_function | kinase activity |
O | 0016310 | biological_process | phosphorylation |
O | 0019877 | biological_process | diaminopimelate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR A 501 |
Chain | Residue |
A | ASP274 |
B | ASN125 |
B | ILE126 |
A | LYS275 |
A | GLY277 |
A | GLU278 |
A | ALA279 |
A | GLN298 |
A | THR308 |
A | HOH613 |
A | HOH622 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE LYS A 601 |
Chain | Residue |
A | MET354 |
A | HIS357 |
A | PRO358 |
A | VAL360 |
A | THR361 |
A | SER381 |
A | GLU382 |
A | HOH610 |
A | HOH621 |
B | ASN43 |
B | ILE44 |
B | ASP45 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE THR B 201 |
Chain | Residue |
A | ASN374 |
A | ILE375 |
B | ASP25 |
B | LYS26 |
B | GLY28 |
B | GLU29 |
B | ALA30 |
B | GLN49 |
B | HOH203 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE THR C 501 |
Chain | Residue |
C | ASP274 |
C | LYS275 |
C | PRO276 |
C | GLY277 |
C | GLU278 |
C | ALA279 |
C | GLN298 |
C | THR308 |
C | HOH622 |
C | HOH623 |
D | ASN125 |
D | ILE126 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE LYS C 601 |
Chain | Residue |
C | MET354 |
C | HIS357 |
C | PRO358 |
C | VAL360 |
C | THR361 |
C | SER381 |
C | GLU382 |
C | ILE385 |
C | HOH609 |
D | ASN43 |
D | ILE44 |
D | ASP45 |
D | HOH272 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR D 201 |
Chain | Residue |
C | ASN374 |
C | ILE375 |
D | ASP25 |
D | LYS26 |
D | PRO27 |
D | GLY28 |
D | GLU29 |
D | ALA30 |
D | GLN49 |
D | HOH204 |
D | HOH317 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE THR E 501 |
Chain | Residue |
E | ASP274 |
E | LYS275 |
E | PRO276 |
E | ALA279 |
E | GLN298 |
F | ASN125 |
F | ILE126 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE LYS E 601 |
Chain | Residue |
E | MET354 |
E | HIS357 |
E | PRO358 |
E | GLY359 |
E | VAL360 |
E | THR361 |
E | THR380 |
E | SER381 |
E | GLU382 |
E | ILE385 |
F | ASN43 |
F | ILE44 |
F | ASP45 |
site_id | AC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR F 201 |
Chain | Residue |
E | ASN374 |
E | ILE375 |
F | ILE23 |
F | ASP25 |
F | LYS26 |
F | PRO27 |
F | GLY28 |
F | GLU29 |
F | ALA30 |
F | GLN49 |
F | HOH606 |
site_id | BC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR G 501 |
Chain | Residue |
G | ASP274 |
G | LYS275 |
G | PRO276 |
G | GLY277 |
G | GLU278 |
G | ALA279 |
G | GLN298 |
G | HOH608 |
G | HOH627 |
H | ASN125 |
H | ILE126 |
site_id | BC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE LYS G 601 |
Chain | Residue |
G | MET354 |
G | HIS357 |
G | PRO358 |
G | VAL360 |
G | THR361 |
G | SER381 |
G | GLU382 |
G | ARG384 |
G | ILE385 |
H | ASN43 |
H | ILE44 |
H | ASP45 |
H | HOH345 |
site_id | BC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE THR H 201 |
Chain | Residue |
G | ASN374 |
G | ILE375 |
H | ASP25 |
H | LYS26 |
H | PRO27 |
H | GLY28 |
H | GLU29 |
H | ALA30 |
H | GLN49 |
H | THR59 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE THR I 501 |
Chain | Residue |
I | ASP274 |
I | LYS275 |
I | GLY277 |
I | GLU278 |
I | ALA279 |
I | GLN298 |
I | THR308 |
J | ASN125 |
J | ILE126 |
site_id | BC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR J 201 |
Chain | Residue |
I | ASN374 |
I | ILE375 |
J | ASP25 |
J | LYS26 |
J | GLY28 |
J | GLU29 |
J | ALA30 |
J | GLN49 |
J | THR59 |
J | HOH374 |
J | HOH375 |
site_id | BC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE THR K 501 |
Chain | Residue |
K | ASP274 |
K | LYS275 |
K | GLY277 |
K | GLU278 |
K | ALA279 |
K | GLN298 |
K | HOH609 |
K | HOH617 |
L | ASN125 |
L | ILE126 |
site_id | BC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE LYS K 601 |
Chain | Residue |
K | MET354 |
K | HIS357 |
K | GLY359 |
K | VAL360 |
K | THR361 |
K | SER381 |
K | HOH624 |
K | HOH627 |
L | ASN43 |
L | ILE44 |
L | ASP45 |
site_id | BC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE THR L 201 |
Chain | Residue |
K | ASN374 |
K | ILE375 |
K | HOH641 |
L | ASP25 |
L | LYS26 |
L | PRO27 |
L | GLY28 |
L | GLU29 |
L | ALA30 |
L | GLN49 |
L | THR59 |
L | HOH202 |
site_id | BC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR M 501 |
Chain | Residue |
M | ASP274 |
M | LYS275 |
M | PRO276 |
M | GLY277 |
M | GLU278 |
M | ALA279 |
M | GLN298 |
M | THR308 |
M | HOH613 |
N | ASN125 |
N | ILE126 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE LYS M 601 |
Chain | Residue |
M | MET354 |
M | HIS357 |
M | PRO358 |
M | VAL360 |
M | THR361 |
M | SER381 |
M | GLU382 |
N | ASN43 |
N | ILE44 |
N | ASP45 |
site_id | CC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR N 201 |
Chain | Residue |
M | ASN374 |
M | ILE375 |
N | ASP25 |
N | LYS26 |
N | GLY28 |
N | GLU29 |
N | ALA30 |
N | GLN49 |
N | THR59 |
N | HOH210 |
N | HOH215 |
site_id | CC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE THR O 501 |
Chain | Residue |
O | LYS275 |
O | GLY277 |
O | GLU278 |
O | ALA279 |
O | GLN298 |
O | THR308 |
P | ASN125 |
P | ILE126 |
site_id | CC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE LYS O 601 |
Chain | Residue |
O | MET354 |
O | LYS355 |
O | PRO358 |
O | GLY359 |
O | VAL360 |
O | THR361 |
O | THR380 |
O | SER381 |
O | GLU382 |
O | HOH605 |
P | ASN43 |
P | ILE44 |
P | ASP45 |
site_id | CC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THR P 201 |
Chain | Residue |
O | ASN374 |
O | ILE375 |
P | ASP25 |
P | LYS26 |
P | PRO27 |
P | GLY28 |
P | GLU29 |
P | ALA30 |
P | GLN49 |
P | THR59 |
P | HOH346 |
Functional Information from PROSITE/UniProt
site_id | PS00324 |
Number of Residues | 9 |
Details | ASPARTOKINASE Aspartokinase signature. VqKYGGSSL |
Chain | Residue | Details |
A | VAL5-LEU13 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
B | ASP25 | |
A | ASP274 | |
C | LYS7 | |
C | ARG25 | |
C | SER41 | |
C | GLU74 | |
C | LEU125 | |
C | ARG151 | |
C | SER174 | |
C | TYR180 | |
C | LYS210 | |
D | ASP25 | |
C | ASP274 | |
E | LYS7 | |
E | ARG25 | |
E | SER41 | |
E | GLU74 | |
E | LEU125 | |
E | ARG151 | |
E | SER174 | |
E | TYR180 | |
E | LYS210 | |
F | ASP25 | |
E | ASP274 | |
G | LYS7 | |
G | ARG25 | |
G | SER41 | |
G | GLU74 | |
G | LEU125 | |
G | ARG151 | |
G | SER174 | |
G | TYR180 | |
G | LYS210 | |
H | ASP25 | |
G | ASP274 | |
I | LYS7 | |
I | ARG25 | |
I | SER41 | |
I | GLU74 | |
I | LEU125 | |
I | ARG151 | |
I | SER174 | |
I | TYR180 | |
I | LYS210 | |
J | ASP25 | |
I | ASP274 | |
K | LYS7 | |
K | ARG25 | |
K | SER41 | |
K | GLU74 | |
K | LEU125 | |
K | ARG151 | |
K | SER174 | |
K | TYR180 | |
K | LYS210 | |
L | ASP25 | |
K | ASP274 | |
M | LYS7 | |
M | ARG25 | |
M | SER41 | |
M | GLU74 | |
M | LEU125 | |
M | ARG151 | |
M | SER174 | |
M | TYR180 | |
M | LYS210 | |
N | ASP25 | |
M | ASP274 | |
O | LYS7 | |
O | ARG25 | |
O | SER41 | |
O | GLU74 | |
O | LEU125 | |
O | ARG151 | |
O | SER174 | |
O | TYR180 | |
O | LYS210 | |
P | ASP25 | |
O | ASP274 | |
A | LYS210 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | BINDING: |
Chain | Residue | Details |
B | ASN43 | |
D | SER132 | |
F | ASN43 | |
F | GLN49 | |
F | VAL111 | |
F | ASN125 | |
F | SER132 | |
H | ASN43 | |
H | GLN49 | |
H | VAL111 | |
H | ASN125 | |
B | GLN49 | |
H | SER132 | |
J | ASN43 | |
J | GLN49 | |
J | VAL111 | |
J | ASN125 | |
J | SER132 | |
L | ASN43 | |
L | GLN49 | |
L | VAL111 | |
L | ASN125 | |
B | VAL111 | |
L | SER132 | |
N | ASN43 | |
N | GLN49 | |
N | VAL111 | |
N | ASN125 | |
N | SER132 | |
P | ASN43 | |
P | GLN49 | |
P | VAL111 | |
P | ASN125 | |
B | ASN125 | |
P | SER132 | |
K | ASN374 | |
K | SER381 | |
M | ASP45 | |
M | SER154 | |
M | ASN292 | |
M | GLN298 | |
M | VAL360 | |
M | ASN374 | |
M | SER381 | |
B | SER132 | |
O | ASP45 | |
O | SER154 | |
O | ASN292 | |
O | GLN298 | |
O | VAL360 | |
O | ASN374 | |
O | SER381 | |
D | ASN43 | |
D | GLN49 | |
D | VAL111 | |
D | ASN125 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | SITE: Contribution to the catalysis => ECO:0000250 |
Chain | Residue | Details |
A | LYS7 | |
I | GLU74 | |
K | LYS7 | |
K | GLU74 | |
M | LYS7 | |
M | GLU74 | |
O | LYS7 | |
O | GLU74 | |
A | GLU74 | |
C | LYS7 | |
C | GLU74 | |
E | LYS7 | |
E | GLU74 | |
G | LYS7 | |
G | GLU74 | |
I | LYS7 |