3TM2
Crystal structure of mature ThnT with a covalently bound product mimic
Summary for 3TM2
Entry DOI | 10.2210/pdb3tm2/pdb |
Related | 3S3U |
Descriptor | cysteine transferase, (2R)-N-(4-chloro-3-oxobutyl)-2,4-dihydroxy-3,3-dimethylbutanamide (3 entities in total) |
Functional Keywords | dom-fold, amidohydrolase, autoproteolytic, carbapenem, pantetheine, inhibitor, dmpa/oat superfamily, pantetheine hydrolase, thienamycin biosynthesis, o-(2-oxo-4-pantoamindobutyl)threonine, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Streptomyces cattleya |
Total number of polymer chains | 2 |
Total formula weight | 83247.57 |
Authors | Schildbach, J.F.,Wright, N.T.,Buller, A.R. (deposition date: 2011-08-30, release date: 2012-07-04, Last modification date: 2023-09-13) |
Primary citation | Buller, A.R.,Labonte, J.W.,Freeman, M.F.,Wright, N.T.,Schildbach, J.F.,Townsend, C.A. Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis. J.Mol.Biol., 422:508-518, 2012 Cited by PubMed: 22706025DOI: 10.1016/j.jmb.2012.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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