4E45

Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM

Summary for 4E45

Related4E44
DescriptorCentromere protein S, Centromere protein X, Fanconi anemia group M protein, ... (6 entities in total)
Functional Keywordshistone-fold, pentamer, fanconi anemia, helicase, fancm, mhf, dna binding protein-hydrolase complex, dna binding protein/hydrolase
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q8N2Z9 A8MT69 Q8IYD8
Total number of polymer chains15
Total molecular weight182335.39
Authors
Fox III, D.,Zhao, Y.,Yang, W.,Weidong, W. (deposition date: 2012-03-12, release date: 2013-03-20, Last modification date: 2018-01-24)
Primary citation
Fox III, D.,Yan, Z.,Ling, C.,Zhao, Y.,Lee, D.Y.,Yang, W.,Weidong, W.
Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.245201.2%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report