4E45
Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, F, H, K... | Centromere protein S | polymer | 112 | 13042.7 | 6 | UniProt (Q8N2Z9) Pfam (PF15630) In PDB | Homo sapiens (human) | CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1, FANCM-interacting histone fold protein 1, Fanconi anemia-associated polypeptide of 16 kDa |
2 | B, D, G, I, L... | Centromere protein X | polymer | 83 | 9116.5 | 6 | UniProt (A8MT69) Pfam (PF09415) In PDB | Homo sapiens (human) | CENP-X, FANCM-interacting histone fold protein 2, Fanconi anemia-associated polypeptide of 10 kDa, Retinoic acid-inducible gene D9 protein homolog, Stimulated by retinoic acid gene 13 protein homolog |
3 | E, J, O | Fanconi anemia group M protein | polymer | 137 | 16333.2 | 3 | UniProt (Q8IYD8) Pfam (PF16783) In PDB | Homo sapiens (human) | Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog |
4 | B, H | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | D, J, N | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
6 | water | water | 18.0 | 546 | Chemie (HOH) |
Sequence modifications
A, C, F, H, K, M: 1 - 110 (UniProt: Q8N2Z9)
B, D, G, I, L, N: 1 - 81 (UniProt: A8MT69)
E, J, O: 667 - 800 (UniProt: Q8IYD8)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 664 | - | expression tag |
Ala 665 | - | expression tag |
Met 666 | - | expression tag |
Pro 668 | Gly 668 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 15 |
Total formula weight | 181955.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 380.4 | |
All* | Total formula weight | 182335.4 |