5FGO
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3BRG
| CSL (RBP-Jk) bound to DNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3'), DNA (5'-D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'), ... | 著者 | Friedmann, D.R, Kovall, R.A. | 登録日 | 2007-12-21 | 公開日 | 2008-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex. J.Biol.Chem., 283, 2008
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7XUZ
| Crystal structure of a HDAC4-MEF2A-DNA ternary complex | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | 登録日 | 2022-05-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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4NFZ
| Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10 | 分子名称: | MANGANESE (II) ION, Polymerase PA | 著者 | Tefsen, B, Lu, G, Zhu, Y, Haywood, J, Zhao, L, Deng, T, Qi, J, Gao, G.F. | 登録日 | 2013-11-01 | 公開日 | 2013-12-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity J.Virol., 88, 2014
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7Z6I
| Crystal structure of p38alpha C162S in complex with SB20358 and CAS 2094667-81-7 (behind catalytic site; Y35 in), P 21 21 21 | 分子名称: | 4-[4-(4-fluorophenyl)-2-[4-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]-1~{H}-imidazol-5-yl]pyridine, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide | 著者 | Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. | 登録日 | 2022-03-11 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
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7Z9T
| Crystal structure of p38alpha C162S in complex with ATPgS and CAS 2094667-81-7 (in catalytic site, Y35 out), P 1 21 1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide | 著者 | Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. | 登録日 | 2022-03-21 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
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6K1K
| Human nucleosome core particle with H2A.X S139E variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6JWP
| crystal structure of EGOC | 分子名称: | Ego2, GTP-binding protein GTR1, GTP-binding protein GTR2, ... | 著者 | Zhang, T, Ding, J. | 登録日 | 2019-04-21 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases. Sci Adv, 5, 2019
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6K1J
| Human nucleosome core particle with H2A.X variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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3TG5
| Structure of SMYD2 in complex with p53 and SAH | 分子名称: | Cellular tumor antigen p53, GLYCEROL, N-lysine methyltransferase SMYD2, ... | 著者 | Zhao, K, Wang, L. | 登録日 | 2011-08-17 | 公開日 | 2011-08-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011
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6KL7
| Beta-arrestin 1 mutant S13D/T275D | 分子名称: | 1,2-ETHANEDIOL, BARIUM ION, Beta-arrestin-1 | 著者 | Kang, H, Choi, H.J. | 登録日 | 2019-07-29 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | 主引用文献 | Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins. Structure, 28, 2020
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3GCQ
| Human P38 MAP kinase in complex with RL45 | 分子名称: | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | 登録日 | 2009-02-22 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J.Am.Chem.Soc., 131, 2009
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6K1I
| Human nucleosome core particle with gammaH2A.X variant | 分子名称: | CHLORIDE ION, DNA (147-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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3GCV
| Human P38 MAP Kinase in Complex with RL62 | 分子名称: | 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | 登録日 | 2009-02-22 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J.Am.Chem.Soc., 131, 2009
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1VCB
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2HW3
| T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position) | 分子名称: | 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*TP*T)-3', 5'-D(*GP*TP*A*CP*(6OG)P*AP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', DNA Polymerase I, ... | 著者 | Warren, J.J, Forsberg, L.J, Beese, L.S. | 登録日 | 2006-07-31 | 公開日 | 2006-12-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | The structural basis for the mutagenicity of O6-methyl-guanine lesions. Proc.Natl.Acad.Sci.Usa, 103, 2006
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6Z6F
| HDAC-PC | 分子名称: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | 著者 | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | 登録日 | 2020-05-28 | 公開日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6Z6O
| HDAC-TC | 分子名称: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | 著者 | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | 登録日 | 2020-05-28 | 公開日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6Z6H
| HDAC-DC | 分子名称: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | 著者 | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | 登録日 | 2020-05-28 | 公開日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (8.55 Å) | 主引用文献 | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6TPA
| CDK8/CyclinC in complex with drug ETP-50775 | 分子名称: | (2~{R})-butane-1,2-diol, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, Cyclin-C, ... | 著者 | Munoz, I.G, Pastor, J, Martinez, S. | 登録日 | 2019-12-12 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur.J.Med.Chem., 201, 2020
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3BTS
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3UVQ
| Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative | 分子名称: | Mitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside | 著者 | Mayer-Wrangowski, S.C, Richters, A, Gruetter, C, Rauh, D. | 登録日 | 2011-11-30 | 公開日 | 2012-12-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J.Med.Chem., 56, 2013
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6GWS
| Crystal structure of human PCNA in complex with three p15 peptides | 分子名称: | PCNA-associated factor, Proliferating cell nuclear antigen | 著者 | De March, M, Merino, N, Gonzalez-Magana, A, Romano-Moreno, M, Onesti, S, Blanco, F.J, De Biasio, A. | 登録日 | 2018-06-25 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | p15PAF binding to PCNA modulates the DNA sliding surface. Nucleic Acids Res., 46, 2018
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3GCP
| Human P38 MAP Kinase in Complex with SB203580 | 分子名称: | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Gruetter, C, Simard, J.R, Rauh, D. | 登録日 | 2009-02-22 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J.Am.Chem.Soc., 131, 2009
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7WJV
| Crystal structure of human liver FBPase complexed with an covalent inhibitor | 分子名称: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | 著者 | Cao, H, Huang, Y, Ren, Y, Wan, J. | 登録日 | 2022-01-08 | 公開日 | 2022-07-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.724 Å) | 主引用文献 | N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. J.Med.Chem., 65, 2022
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