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3UVQ

Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative

Summary for 3UVQ
Entry DOI10.2210/pdb3uvq/pdb
Related3QUD 3QUE 3UVP 3UVR 3UVS
DescriptorMitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywordsselective p38 inhibitor, sar, dibenzosuberone derivative, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight42087.98
Authors
Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (deposition date: 2011-11-30, release date: 2012-12-05, Last modification date: 2023-11-08)
Primary citationFischer, S.,Wentsch, H.K.,Mayer-Wrangowski, S.C.,Zimmermann, M.,Bauer, S.M.,Storch, K.,Niess, R.,Koeberle, S.C.,Grutter, C.,Boeckler, F.M.,Rauh, D.,Laufer, S.A.
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.
J.Med.Chem., 56:241-253, 2013
Cited by
PubMed: 23270382
DOI: 10.1021/jm301539x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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