3UVQ
Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative
Summary for 3UVQ
Entry DOI | 10.2210/pdb3uvq/pdb |
Related | 3QUD 3QUE 3UVP 3UVR 3UVS |
Descriptor | Mitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | selective p38 inhibitor, sar, dibenzosuberone derivative, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42087.98 |
Authors | Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (deposition date: 2011-11-30, release date: 2012-12-05, Last modification date: 2023-11-08) |
Primary citation | Fischer, S.,Wentsch, H.K.,Mayer-Wrangowski, S.C.,Zimmermann, M.,Bauer, S.M.,Storch, K.,Niess, R.,Koeberle, S.C.,Grutter, C.,Boeckler, F.M.,Rauh, D.,Laufer, S.A. Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J.Med.Chem., 56:241-253, 2013 Cited by PubMed: 23270382DOI: 10.1021/jm301539x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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