3QUE

Human p38 MAP Kinase in Complex with Skepinone-L

Summary for 3QUE

Entry DOI	10.2210/pdb3que/pdb
Related	3QUD
Descriptor	Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, ... (4 entities in total)
Functional Keywords	kinase domain, phosphate transferase, dibenzosuberone derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42279.22
Authors	Gruetter, C.,Mayer-Wrangowski, S.,Richters, A.,Rauh, D. (deposition date: 2011-02-23, release date: 2012-01-18, Last modification date: 2023-11-01)
Primary citation	Koeberle, S.C.,Romir, J.,Fischer, S.,Koeberle, A.,Schattel, V.,Albrecht, W.,Grutter, C.,Werz, O.,Rauh, D.,Stehle, T.,Laufer, S.A. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat.Chem.Biol., 8:141-143, 2012 Cited by PubMed: 22198732 DOI: 10.1038/nchembio.761 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation