7WJV

Crystal structure of human liver FBPase complexed with an covalent inhibitor

Summary for 7WJV

• Entry DOI: 10.2210/pdb7wjv/pdb
• Descriptor: Fructose-1,6-bisphosphatase 1, ADENOSINE MONOPHOSPHATE, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ... (7 entities in total)
• Functional Keywords: classification: hydrolase organism(s): homo sapiens expression system: escherichia coli bl21(de3) inhibitor: covalent binding c128, cytosolic protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 154875.51

Authors

Cao, H.,Huang, Y.,Ren, Y.,Wan, J. (deposition date: 2022-01-08, release date: 2022-07-13, Last modification date: 2023-11-29)

• Primary citation: Wen, W.,Cao, H.,Xu, Y.,Ren, Y.,Rao, L.,Shao, X.,Chen, H.,Wu, L.,Liu, J.,Su, C.,Peng, C.,Huang, Y.,Wan, J.; N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.; J.Med.Chem., 65:9126-9143, 2022; PubMed: 35786925; DOI: 10.1021/acs.jmedchem.2c00336

Experimental method

X-RAY DIFFRACTION (1.724 Å)